A harm minimization approach to substance abuse treatment has three main objectives: 1) To minimize harm to individuals and communities from drug use, 2) To reduce hazardous drug use patterns in the community, and 3) To prevent initiation of harmful drug use especially among youth. Examples of harm reduction strategies include needle exchange programs, opioid substitution therapy, and overdose prevention programs. Research on therapeutic communities shows benefits for those who complete treatment, though dropout rates are high, suggesting multiple treatment attempts may be needed. Relapse prevention therapy aims to reduce relapse risk by addressing cravings, thoughts, and high-risk situations. Effective substance abuse treatment is individualized, readily available, and addresses multiple needs through continual assessment and modification.