cholesterol synthesis
- 2. Introduction ž Cholesterol is constituent of all cell membrane. Necessary for synthesis of steroid hormones, bile salts and Vitamin D. Normal level <200mg/dl. Abnormality of cholesterol metabolism may lead to cardiovascular disease and heart attacks.
- 3. Functions of Cholesterol ž Cholesterol packs phospholipids from both the sides of cell membrane and therefore maintains stability and stiffness of cell. ž Cholesterol is responsible for proper synthesis of neurotransmitters. ž Cholesterol plays an important role in synthesis of Vitamin D3 and hormones including aldosterone, cortisol, estrogen, cortisone, progesterone. ž Cholesterol is a precursor to other vital molecules that are important for functioning of the body
- 4. Structure of cholesterol ž Its molecular formula is C27H46O. Cholesterol contains steroid rings with a hydroxyl group, two methyl groups and a hydrogen tail.
- 6. Synthesis Biosynthesis of cholestrol is considered a Complex method. The carbon atoms in cholestrol structure provided by single precursor ACETYL CoA. Synthesis of cholestol can be studied conveniently in 5 stages~ ž Formation of HMG CoA ž Synthesis of mevalonate ž Generation of isoprenoid units ž Synthesis of squalene ž Formation of cholesrol
- 9. Fate of Cholesterol ž Cholesterol can be exported and transported to other tissues via LDL ž Converted to bile acids and secreted into the intestines. ž Used up in formation of cell membrane. ž Used in formation of VIT.D and steroid hormones.
- 10. QUESTION Q)Ring system of cholesterol is known as- A) Cholanthrene ring B) Cyclopentano phenanthrene C) Napthoquinone D) Corrin ring
- 11. key enzyme in pathway of cholesterol biosynthesis is?
- 12. THANKS GENIUSES