This document provides guidance for preceptors on building effective relationships with preceptees, managing burnout, and developing cultural competence and emotional intelligence. It identifies strategies for establishing trust, communicating well, and managing conflict. Preceptors should acknowledge cultural differences, engage in self-assessment, and understand behavior in cultural context. Burnout can be reduced by self-assessing, fueling resilience through revisiting teaching goals, and developing plans for busy days. Preceptors should discuss and practice these relationship-building and self-care strategies.