This paper presents a comparative study of four topologies of single-phase five-level inverters: diode clamped, flying capacitor, cascaded H-bridge, and phase opposition disposition (POD) inverter, focusing on their total harmonic distortion (THD) and component utilization. The simulation results, conducted using MATLAB/Simulink, indicate that the POD PWM H-bridge topology exhibits the lowest THD, making it a suitable choice for high power applications. Overall, the study suggests that adopting the POD technique can lead to lower costs, reduced semiconductor device usage, and improved efficiency in multilevel inverter design.