The document compares the total cost of ownership of physical, virtual, and cloud-hosted desktops. It finds that virtual desktops can reduce costs by up to 36% over physical desktops, while cloud desktops deliver further savings of over 20% compared to on-premises virtual desktop infrastructure. On-premises VDI has high upfront infrastructure costs that offset labor savings, while cloud desktops have no infrastructure investment and provide the lowest total cost of ownership through a pay-as-you-go model.