This white paper discusses essential elements for optimizing data center operations, including airflow management, data center infrastructure management (DCIM) tools, power management, and operational best practices. It focuses on recent government initiatives like the Data Center Optimization Initiative (DCOI) that mandate increased energy efficiency in federal data centers through metrics like power usage effectiveness (PUE). The paper examines strategies like hot/cold aisle containment and cloud migration that can help data centers improve optimization and meet new efficiency requirements.