Computational Dual-system Imaging Processing Methods for Lumbar Spine Specimens with Medical Physics Applications

© 2021, AJCSE. All Rights Reserved 60
RESEARCH ARTICLE
Computational Dual-system Imaging Processing Methods for Lumbar Spine
Specimens with Medical Physics Applications
Francisco Casesnoves
Independent Research Scientist Engineering-Physics-Software; International Association of Advanced
Materials, Sweden; Uniscience Global Scientific Member, Wyoming, USA; Harjumaa, Estonia
Received on: 25-10-2021; Revised on: 30-11-2021; Accepted on: 29-12-2021
ABSTRACT
Based on previous studies, a comparative-series of improved imaging-computational for new/different
lumbar cadaveric specimens was obtained with two systems—namely Matlab and GNU-Octave.
Algorithmic methods for program patterns are improved and developed. Results comprise a biomedical
study of each and every lumbar cadaveric specimen with contrasted evaluation for both computational
systems. Imaging processing methods for resolution in improved vertebral contrast/facets/positioning,
vertebral-anatomical parts separation, visualization of lumbar spines, and different 3D imaging options
available,areexplainedandproven.InClinicalMedicalPhysicsandComputationalAnatomicalPathology,
these advances associated to improve previous imaging contributions and statistical data are demonstrated.
Results show sharply the usage of Matlab and GNU-Octave imaging processing, programming codes/
patterns, and computer vision tools. Efficacious utility of these computational-software imaging methods,
useful/appropriate for clear/detailed anatomical-clinical analysis, and comparisons among cadaveric
specimens are illustrated along an imaging series. The anatomical dissection methods previously
published obtain additional procedures/applications in lumbar vertebra study, statistics, and surgical tools
manufacturing. Applications on Medical Physics, Biomedical Engineering, and Computational-Forensic
Diagnosis are got from this dual cadaveric imaging systematic comparison. Matlab and GNU-Octave
software 3D imaging methods utility are explained/extrapolated for other type of usages.
Key words: Computational anatomical dissection, Image processing, Software engineering, Surfactal
Programming, Computer aided design, Computer aided manufacturing, Anatomical cadaveric imaging
simulations, Biomechanics, Bioengineering, Spinal computational-surgery, Spinal ligaments, Spinal
anterior longitudinal ligament
INTRODUCTION AND SPINAL
BIOMECHANICS ANALYSIS
A series of previous publications[1-12]
in Surfactal
computer aided design (CAD) and computer
aided manufacturing (CAM) presented 3D
imaging methods to obtain biomechanical,
clinical medical physics, anatomical systematic
study, and forensic analysis of lumbar cadaveric
specimens. The anatomy of vertebra differs
systematically for every part of spine. The most
dissimilar are the cervical ones, while thoracic
and lumbar vertebras show more resemblance.
Any vertebra can be characterized for a number
Address for correspondence:
Francisco Casesnoves,
E-mail: casesnoves.research.emailbox@gmail.com
of anatomical shape peculiarities. These are
vertebral body, dimension, pedicles, facets, facet-
curvature, ligaments that support it, ligament
insertion zone, spinal cord channel size, geometry
at different stages of lifetime, or any pathological/
non-pathological particular patient sign.[1]
Moreover, during lifetime, the vertebra shape and
histology experience changes together with the
whole spine in general. Lumbar vertebra loads
are about 500 N, and this biomechanical factor
causes a significant deformation during lifetime.
The changes of the intervertebral disks are more
considerable as disks support these loads and have
a deformable histological structure. Therefore,
the bioinformatics study at every life stage can
provide database for surgical theatre pre- and
post-operative planning and/or instrumentation
manufacturing.
Available Online at www.ajcse.info
Asian Journal of Computer Science Engineering 2021;6(4):60-71
ISSN 2581 – 3781

Casesnoves: Computational Dual-system Imaging Processing Methods for Lumbar Spine Specimens with Medical PhysicsApplications
AJCSE/Oct-Dec-2021/Vol 6/Issue 4 61
The spinal pathology study can obtain valuable
data from the analysis of anatomical/physiological
changes during average lifetime. Preventive and
statistical medicine also gets substantial evidence
from this database and CAD imaging analysis.
CAD and CAM are widely used, for instance,
for design of spinal prostheses, devices, tools,
orthopedics apparatus, pediatric orthopedics,
and spinal stabilization devices. That is, new
prostheses, surgical-theatre tools, spinal screws,
stabilization kits, artificial intervertebral disks,
grips, etc., CAD, based on anatomical data, is
useful/efficacious for accurate affix of spinal
prostheses/devices—fitting error and post-surgical
complications are then reduced.
This contribution differs from the former studies
in objectives and results. That is, the paper aim
is focused on computer vision tools and digital
imaging processing usage for getting digital
database from lumbar cadaveric specimens.
Digital anatomical records from the imaging
laboratory apparatus, for example, a scanner are
important and constitute the first stage for these
purposes. However, if they are not conveniently
computationally analyzed/software-implemented
to set high-quality representations/images with
good numerical approximations database is
not suitably managed. Figure 1 shows a CAD
hyperbolic vertebral body model to set the
cadaveric specimen digital data for a geometrical
model of a hyperboloid.[10]
Hence, this study proves how computer vision
tools and image processing are efficacious to
get/extract clinical information from lumbar
cadaveric specimens. The characteristics that are
studied are mainly lumbar spine specimen shape,
vertebra pathology, arthrosis traces/damage, facet
curvature and degeneration, vertebra and disk
deformation, disk protrusion, pedicles, traces
of ALL, ligaments, and other applicable data in
clinical medical physics. All these methods are
applied with two systems, Matlab and GNU-
Octave. In addition, a comparative assessment of
these two programming systems functionality is
presented.
In summary, this study shows usage/utility of a
number of imaging processing and CAD vision
tools to examine and extract medical-surgical
information from lumbar cadaveric specimens. It is
based on program codes, subroutines applications,
options best optimization, and programming
patterns. Two computational systems for these
objectives are applied and contrasted, Matlab
and GNU-Octave. Moreover, pre-hypotheses/
extrapolated applications for future clinical
medical physics and surgical applications are
suggested/explained. Results and images, system
comparisons, and programming techniques can
be considered acceptable both for bioengineering
advances and lumbar/general spinal surgery
applications.
CLOUD DATA CADAVERIC SPECIMEN
MATERIALS
Matlab scanning cloud data
As in previous studies,[3,8-12]
a digital scanner
apparatus was the experimental method to select
numerical data. The laboratory method was
obtained the cadaveric specimens cloud data of
lumbar spines with the digital scanner, once the
anterior part of the specimens was exposed to
waves. The CAD surfactal fit was obtained from
Figure 1: From,a polynomial computer aided design (CAD) model for a region of interest, of the vertebral body of a lumbar
spine specimen. The polynomial fit was made with a CAD method taking the digital scanned data from the specimen

different and also previous anterior vertebral
body anatomic samples. The cloud data of this
experimental samples, as in,[3,8-12]
were obtained
using high resolution in the 3D Scanner Digitizer
(high resolution was ≃10-7 m
). In most cases, the
data obtained of the spine surfaces had ≃105
points for each specimen. For Matlab and GNU-
Octave comparative study, the specimen 1 has
about 16350 3D points. The specimen 2 has
approximately 16300 3D cloud points.
With interpolation algebraic methods, cloud
point number is condensed from ≃105
to ≃104
to
increase the visualization program image-set and
speed. The reduction of point’s algebraic method
was performed by interpolation software, taking
approximate middle points among intervals. In
previous contributions, extent developments of
the specimens for computational programs were
carried out.[3-5,8-12]
The objective was to interpolate
the cloud data to optimize the imaging processing
tools usage, and not all the specimens have the
same interpolation parameters, since the 3D cloud
data number differs for everyone.
GNU-octave scanning cloud data
For computational comparisons, a new specimen
was added to contrast imaging vision processing
between GNU-Octave and Freemat.This specimen
was studied in Matlab in previous contributions.[3-8]
Number of digital cloud 3D data is 14055. Cloud
point number is reduced from ≃105
to ≃104
to
increase the visualization program speed. This
cloud data specimen was prepared exclusively
to prove the functionality of GNU-Octave 3D
imaging process. The previous sub-section data
for specimens 1 and 2 were also programmed in
GNU-Octave.
MATHEMATICAL METHODS AND
IMAGING SOFTWARE
Both in Matlab and GNU-Octave, image
processing, and computer vision tools were the
principal implement to obtain the images and
use the Matlab camera settings. For Matlab, the
programming method was based on both classical
3D tools, and camera settings—, appropriate
subroutines and a group of commands/sentences
to set spinal 3D images accurately. For GNU-
Octave, the camera images similar to Matlab
require laborious task. Matlab and GNU-Octave
programming techniques are based on previous
contributions and literature.[2,4-16]
In Matlab, the
following imaging processing settings were
used: Zoom, rolling, projections along axes,
orbit, tilt, moving (horizontal, vertical, forward,
backwards), definition of principal axes,
imaging contrast and tiles size. In GNU-Octave,
rotation, pan, text box, toggle, zoom in-out,
and commands/options for color, tiles, image
definition, etc. Table 1 shows a comparative set
of Matlab and GNU-Octave reference-standard
algorithms, functions, tools, and applications for
image processing, analysis, visualization, and
algorithm developments.
For Matlab, the average running time for a
cadaveric image was 2–10 s. For GNU-Octave, it
is at least 15 s, depending of the amount of 3D
subroutine options. In Matlab, the image tools time
Table 1: Computer vision tools used for images.
Upper, Matlab imaging processing methods. Lower,
GNU‑Octave imaging tools
MATLAB computational image and vision techniques
Vertebral length To be determined by number of cloud data and tiles size
Lumbar spine
positioning
All projections along axes, orbit, tilt,
moving (horizontal, vertical, forward, backward)
Vertebral facets Projections along axes, orbit, tilt,
Disks Projections along axes, orbit, tilt,
Arthrosis
osteopathy
degeneration
signs
Contrast, tilt, zoom, very easy use and fast
ALL Contrast, tilt, zoom, traces visualized along some
vertebral specimens
GNU‑octave computational image and vision techniques
Vertebral length To be determined by number of cloud data and
tiles size, can be guessed from axes information
Lumbar spine
positioning
All projections along axes, rotation is easy,
no orbit and tilt, moving (horizontal, vertical,
forward, backward),
Vertebral facets projections along axes, there is no orbit and tilt,
Disks No camera projections along axes, no orbit or tilt,
Arthrosis
osteopathy
degeneration
signs
Contrast, zoom is possible but more difficult than
Matlab. It is clearly seen any pathological sign, as
image is very clear.
ALL Traces can be visualized along some vertebral
specimens
Image definition
and text
insertion
Image can be considered very good, and
Text can be inserted but text boxes are difficult
and complicated to set
Pan tool It works fast and provides with facility to displace
the image along axes

Figure 2: (a) Matlab-Method-1.-L5 facet lateral-right image processing separation in specimen 1. Facet imaging-
visualization was optimized setting the tiles division and brightness-color appropriate numerical data in program. The
complete L5 lateral-right facet is shown. Pictured inset, left-up, the lateral-left image. Conservation in general is good with
one arthrosis nodule. Image color, definition, and contrast were got using vision tools in Matlab and proper sentences in
program. The protrusion rounded-nodes at disks have no significance, since are the traces of experimental surgical insertion
tools for other studies. (b) GNU-Octave-Method-1.-L5 facet lateral-right image processing separation in specimen 1. Facet
imaging-visualization was optimized setting the tiles division and brightness-color appropriate numerical data in GNU-
Octave program. The complete L5 lateral-right facet is shown with signs of facet degeneration. Conservation in general is
good with one arthrosis nodule. Image color, definition, and contrast were got by using vision tools in Matlab and proper
sentences in program. The protrusion rounded-nodes at disks have no significance, since are the traces of experimental
surgical insertion tools for other studies. (c) GNU-Octave-Method-2.-L5 facet lateral-right image processing separation in
specimen 1 with Method 2 subroutine. Image is also good and isolines are well defined. Facet imaging-visualization was
optimized setting the tiles division and brightness-color appropriate numerical data in GNU-Octave program. The complete
L5 lateral-right facet is shown. Conservation in general is good with one arthrosis nodule. Image color, definition, and
contrast were got using vision tools in Matlab and proper sentences in program. (d) Matlab-Method-1-Camera.-L5 facet
lateral-right camera-image processing separation in specimen 1 with Method 1 subroutine. It is necessary to vary contrast
and brightness to obtain a similar to Matlab camera image that takes at least 5 min. Image is also good and isolines are well
defined. Facet imaging-visualization was optimized setting the tiles division and brightness-color appropriate numerical data
in GNU-Octave program. The complete L5 lateral-right facet is shown. Conservation in general is good with one arthrosis
nodule. Image color, definition, and contrast were got using vision tools in Matlab and proper sentences in program
b
c
d
a

Table 2: Imaging results for specimen 1 in both systems
MATLAB Computational image processing results specimen 1
Length Standard
Vertebral bodies,
facets
Degenerated, asymmetry, concavity and
convexity deformed
Disks Not significantly herniated but deformed
Pedicles Can be something observed at L5
Arthrosis osteopathy
degeneration
Significant and affecting to all vertebras
Geometrical
distribution
Arthrosis changes are non‑symmetrically
distributed as it is usual in that
degenerative‑disease
Transversal processes Cannot be observed
ALL and PLL Traces can be visualized, PLL (posterior
longitudinal ligament cannot) be visualized
GNU‑octave computational image processing results specimen 1
Length Standard, well defined
Vertebral bodies,
facets
Degenerated, asymmetry, concavity and
convexity deformed, but more difficult to be
set with GNU‑Octave
Disks Not significantly herniated but deformed
Pedicles Cannot be observed at L5
degeneration
Significant and affecting to all vertebras, seen
in camera image
Geometrical
distribution
Transversal
processes
Cannot be observed
Table 3: Imaging results for specimen 2 in both systems.
One previous studies[3,3.1]
specimen is also analyzed
MATLAB computational image processing specimen 2
Length smaller than previous specimens
Vertebral bodies, facets Concavity and convexity deformed, holes
Disks Herniated some of them
Pedicles Can be something observed at L5
degeneration
Significant and affecting to most vertebras
Geometrical distribution Arthrosis changes are non‑symmetrically
GNU‑octave computational image processing results specimen 2
Length Shorter but well defined
Vertebral bodies, facets Degenerated, asymmetry, concavity and
convexity deformed, but more difficult to
be set with GNU‑Octave
Disks Significantly herniated and clearly
deformed
Pedicles Cannot be observed at L5
degeneration
Significant and affecting to all vertebras,
seen in camera image
Geometrical
distribution
Previous study
additional specimen
Figure 10
This specimen from previous studies was
set‑programmed in GNU‑Octave to show
the differences in tissue and ALL traces. It
was obtained also with contour option and
two methods.
to start to work varies significantly. If a text box is
inserted into image, it takes at least 15 s. A cursor
numerical data extraction takes 5 s. In GNU-
Octave, the image tools time to start to work was
about 10–20 s. For Matlab, the positioning change
speed of camera was about 1 s. The division of
numerical intervals for tiles in complete lumbar
specimen image was selected about 0.5 for optimal
visualization and not long running time. In GNU-
Octave, similar images to Matlab camera can be
done, but it takes at least 15–20 s.
MATLAB AND GNU-OCTAVE
COMPARATIVE RESULTS
The findings obtained by imaging software
are presented in a series of computer vision
pictures, Figures 1-8. The compared anatomical-
clinical details of facets, vertebra sizes and body,
pathological signs, ligaments, length, and other are
obtained along the images. Tables 2 and 3 show
the imaging results summary. Figure 8 presents
an special specimen form[3]
that was implemented
for imaging processing patterns. That specimen is
specially longer and shows a sharp protrusion of
all disks [Figures 9-11].
Figure 3: Matlab-Camera. Complete cranial-caudal image
of specimen 1. Image was set with processing tools for
showing better L2 facet. All facet imaging-visualization
was optimized setting the tiles division and brightness-
color appropriate numerical data in program. The complete
L5 facet is shown partially. Image color, definition, and
contrast were got using vision tools and proper sentences in
program

CLINICAL MEDICAL PHYSICS AND
BIOENGINEERING APPLICATIONS
Table 4 shows a brief of applications from.[3,8-17]
Applications can be clinical and for research
in general. Clinical group ones are mainly for
spinal surgery. These are from surgical operation
tools manufacturing till implants, artificial
disks, screws, stabilizers, pediatric orthopedics,
intervertebral disc degenerative process diagnosis,
bone structure degeneration-form, etc.
Research-theoretical utility is related to all
computational software and database for CAM and/
orCADobjectives.Thesecouldbeimplant-materials
optimization, osseointegration optimization, any
prostheses, implant, surgical-theatre conformal
apparatus, or orthopedic stabilizers. Database-
statisticalCADsoftwarefordiagnosis-studyofspinal
pathologies—for example, incidence/prevalence of
pediatric and youngsters spinal diseases evolution,
professional diseases, elderly statistics for spinal
diseases prevalence/incidence, or professional-risk
of spinal damage. The CAM design of interfaces
is essential. Interfaces of stabilizers, surgical tools,
implants, prostheses and orthopedic apparatus
have to fit as much optimal as possible. There are
several types of clamps, grips and screws, namely,
three-point shear clamp, lock screw (with end-
on and tangential parts), circumferential grips,
Figure 4: GNU-Octave-Method-1.-Complete cranial-caudal image of specimen 1, set to show the ALL traces at middle
specimen. Image was set with GNU-Octave processing tools for showing better the facets. All facet imaging-visualization
was optimized setting contrast and the tiles division and brightness-color appropriate numerical data in program. ALL
traces can be also identified when the isolines lose definition. That means that the surface-variability of the non-smooth-
surface ligament histological structure causes loss of isolines definition
Figure 5: Matlab-Camera.-Complete cranial-caudal image of specimen 1, but tilted to show L5 and Sacrum zones. Image
was set with processing tools for showing better L5 facet. All facet imaging-visualization was optimized setting the tiles
division and brightness-color appropriate numerical data in program. The complete L5 facet is shown in first plane. Image
color, definition, and color-contrast were got using vision tools and proper sentences in program

constrained bolt–plate, constrained screw–plate,
semiconstrained screw–plate, semiconstrained
component–rod, component–component Interfaces,
and new recently-designed others.
Optimal interface-precision and bonding is
indispensable.This property avoids complications,
post-operation complications, locking
mechanisms failures, malfunctionality, breaks,
corrosion and tribocorrosion of interfaces, friction
problems, erosion, abrasion, wear of materials,
histocompatibility inmunological reactions, post-
operative rehabilitation and pain, and a wide of
unpredictable post-surgical complication chances.
Deformity prevention and correction in the
specialization of pediatric surgery CAM is
more complicated in general than the adult’s
one. The children organism and constitution is
in dynamic-growing continuous evolution, and
the physical activity of a child is higher than the
adult in general. Computational Biomechanics
and computational dissection CAD and CAM
design constitutes an useful tool to resolve all
these pediatric biomedical pathologies. Statistical
imaging database for pediatric bones is usually
Figure 7: Matlab-Method-1.-L5 facet image processing separation in specimen 2. Facet imaging-visualization was
optimized setting the tiles division and brightness-color appropriate numerical data in program. The complete L5 anterior
facet is shown in first plane. Conservation is good with one arthrosis nodule. Image color, rotation, definition, and contrast
were got using vision tools and proper sentences in program
Figure 6: Matlab-Method-1.-Complete specimen 1 lateral-right imaging processing set. It can be compared to
Figure 4-GNU-Octave-Method-1. The separation of vertebras in this specimen 1 was got sharp with computer vision
tools. Isolines are clear. ALL are marked inset. Facet imaging-visualization was optimized setting the tiles division and
brightness-color appropriate numerical data in program. The state of conservation of facets-vertebras and disks can be
observed. L5 is well preserved, but L4 facet not so well. Color, definition, and contrast were got using vision tools and
proper sentences in the program

Figure 8: (a) Matlab-Method-1.-L2 facet image processing separation in specimen 2. Facet imaging-visualization was
optimized setting the tiles division and brightness-color appropriate numerical data in program. The complete L3 anterior
facet is shown. The lateral L4 facet is marked. Conservation is good with one arthrosis nodule. Image color, definition, and
contrast were got using vision tools and proper sentences in program. Specimen 2 is shorten than specimen 1. (b) GNU-
Octave-Method-1.-L2 facet image processing separation in specimen 2. Facet imaging-visualization was optimized setting
the contrast tiles division and brightness-color appropriate numerical data in program. ALL traces can be easily identified.
The complete L3 anterior facet is shown. The lateral L4 facet is marked. Conservation is good with one arthrosis nodule.
Image color, definition, and contrast were got using contrast and proper sentences in program. Contour lines cannot be seen
because the contrast was increased. Specimen 2 is shorten than specimen 1
a
b
Figure 9: Matlab-camera.- Complete cranial-caudal image of specimen 1, but tilted to show L5 and Sacrum zones. Image
was set with processing tools for showing better L5 facet. L4 is deformed. All facet imaging-visualization was optimized
setting the tiles division and brightness-color appropriate numerical data in program. Image color, definition, and contrast
were got using vision tools and proper sentences in program. Error, in image text it should be written specimen 2

Figure 10: (a) GNU-Octave-Method-1.-Complete cranial-caudal image of specimen from previous publications[3,3.1]
set to
show the ALL traces at middle specimen. Image was set with GNU-Octave processing tools for showing better the facets.
The isolines are not very clearly defined at the middle facets because there is residual tissue in specimen sample. All facet
imaging-visualization was optimized setting contrast and the tiles division and brightness-color appropriate numerical
data in program. ALL traces can be also identified when the isolines lose definition. Contour lines cannot be seen since
contrast was increased. That means that the surface-variability of the non-smooth-surface ligament histological structure
causes loss of isolines definition. (b) GNU-Octave-Method-2.-Complete cranial-caudal image of specimen from previous
publications[3,3.1]
set to show the ALL traces at middle specimen. Image was set with GNU-Octave processing tools for
showing better the facets. The isolines are not very clearly defined at the middle facets because there is residual tissue in
specimen sample. Yellow zone corresponds to ALL and surrounding tissue adhered. Contour lines can be seen clearly. All
facet imaging-visualization was optimized setting contrast and the tiles division and brightness-color appropriate numerical
data in program. ALL traces can be also identified when the isolines lose definition. That means that the surface-variability
of the non-smooth-surface ligament histological structure causes loss of isolines definition
a
b
Figure 11: Matlab-camera.- Complete cranial-caudal image of specimen 1 from,[3.1]
but tilted to show L4-L5 and
Sacrum zones. Image was set with processing tools for showing better all vertebra disks protrusions. L5 is deformed, L4
degenerated. All facet imaging-visualization was optimized setting the tiles division and brightness-color appropriate
numerical data in program. Image color, definition, and contrast were got using vision tools and proper sentences in
program. This specimen from[3.1]
is particularly long and anatomically interesting

more difficult to be obtained. Results of this study
contribute to this research/clinical field.
DISCUSSION AND CONCLUSION
In general, the comparative study has shown the
imaging processing different methods with two
systems. The objective is to obtain useful clinical
and biomedical database from lumbar spine
vertebral specimens. Therefore, the results of the
paper have two main strands. The first comprises
all the clinical and anatomical information that
can be got from the CAD images. The second
is the programming software improvements that
are developed/compared with Matlab and GNU-
Octave 3D imaging subroutines and processing
tools, Figures 9-11.
The biomedical information that can be guessed
for the 3D imaging results is extent. Among them,
general lumbar spine diagnosis/functionality,
determinationofcurvatures,arthrosisdegeneration,
signs, reumathological diseases signs, osteophites,
facet smoothness, concavities geometrical data,
angles of curvature, size of surfaces, and bone-
degeneration/deformation of vertebras. The
pathological signs of facets and disks, such as
degeneration, asymmetry of facets and body
shapes,ordiskherniationconstituteusefulimaging
data. Specially, given the prevalence/incidence of
surgical intervertebral disk pathology, the state
diagnosis of the lumbar disks is important. Just
to remind that the biomechanical loads at lumbar
spine are the statistically highest—in magnitude
order of at least 500 N.[13-19]
As a whole, Matlab shows better facilities for
3D imaging implementation/usage. However, the
differences with GNU-Octave are not excessive.
All this assessment was presented in Sections 3–4.
Both GNU-Octave and Matlab offer two types
of 3D imaging subroutines with a large number
of additional programming options for image
contrast, tiles size, color choices, brightness, etc.
However, the usage of all of these takes more
running time in GNU-Octave than in Matlab. The
3D cloud data of the vertebras offers a number of
research possibilities for data/imaging extraction.
This yields to a number Medical Physics and
Biomedical applications for CAM constitute the
principal applications.
These properties measurement are suitable for new
prostheses, intervertebral disk database, spinal
Table 4: Resume of biomedical and medical physics
applications. Improved from[3,8‑19]
Computational dissection medical physics applications
Spinal surgical pathology field Applications
Bone quality Can be determined approximately
with these methods
Spinal cad All tools and prostheses optimal
design
Spinal cam All tools and prostheses optimal
manufacturing design
Osseointegration optimization Direct bonding of bone to an
implant improvements.
Spine tools and apparatus Spinal instrumentation, implants
and deformity correction
prostheses, implant‑bone optimal
interfaces instrumentation, all kind
of screws, rods, grips, distractors,
screw‑insertion‑angle optimization
for a wide range of implants
Implant materials optimization Study with CAD‑CAM suitability
of implant materials manufacturing
Prostheses All types of implants, artificial
disks, clamps, stabilizers, etc.,
Prevent
Structural injury
Optimization of interfaces and
implant structure can prevent
structural injuries
Surgical tools
And prostheses
Interfaces
This is a practical/important
application
Orthopedics Spondylolisthesis, scoliosis, and
all other types of deformations
orthopedics apparatus
Instrumental forces applications
design
Optimization of surgical tools,
implants, and prostheses to apply
biomechanical and surgeon forces
with precision and without damage/
injury risks
Pre‑operation Pre‑operation computational
simulations/optimization,
pre‑operation design of implants or
necessary new tools at theatre
Post‑operation Complications prevention,
post‑operation tracking, imaging
post‑operation computational
checking, design of necessary
additional post‑operation implants
Rehabilitation Post‑surgery orthopedics
rehabilitation for motion
preservation apparatus, prostheses,
electric‑mechanical implants
Spine deformations All types of spinal tools for
correction or balance
Preventive medicine Statistics for prevention of
incidence/prevalence of spinal
diseases, statistic models for
disease evolution
Surgical theatre work Optimization of all types of
tools functionality, interfaces,
resistance, corrosion protection,
instrumentation ductility and/or
fatigue
Pediatric spinal surgery Deformation, stabilization,
correction prostheses, spinal
pediatry instrumentation in general
Pediatric orthopedics Pediatrics stabilization orthopedics

screws, stabilization kits, artificial intervertebral
disks, grips, etc. Also for precise-mesh surgical
tools manufacturing, spinal stabilization, artificial
implants/prostheses, orthopedic apparatus/
instruments, surgical robotics and computational
preparation/design of surgical intervention.[1-12]
All these results are suitable for clinical medical
physics and biomedical study, and surgical
industry.
In brief, the research has proven the utility
of imaging processing and computer vision
techniques to obtain digital database from lumbar
spine vertebral specimens. The biomedical
and clinical medical physics applications are
efficacious and wide. The software engineering
for 3D imaging processing constitutes an advance
for lumbar spine specimen CAD and CAM.
SCIENTIFIC ETHICS STANDARDS
This contribution is based on Graphical
Visualization-Optimization methods for cadaveric
specimens of lumbar spine with software improved
from previous articles. Graphical-Optimization
MethodswerecreatedbyDr FranciscoCasesnoves
on December 2016. Forensic Robotics Integrated
Systems engineering-concepts were developed
by Casesnoves in July 2020. The new laboratory
specimensaredifferentfrompreviouspublications.
The images of previous contributions,[3]
are set to
compare Matlab camera images with GNU-Octave
vision processing methods. Table 4 is improved/
developed from previous publications clearer.[3]
The picture-illustration processing and computer
vision tools programs and special software to
obtain new images of specimens, positioning,
panoramic vision, enhancement of selected
vertebras, or imaging tiles optimization was
originally developed by author. This comparative-
advanced article has a few previous paper
information, whose inclusion is essential to make
the contribution understandable. This study was
carried out, and their contents are done according
to the European Union Technology and Science
Ethics. Reference, “European Textbook on Ethics
in Research.” European Commission, Directorate-
General for Research. Unit L3. Governance and
Ethics. European Research Area. Science and
Society. EUR 24452 EN. Also based on The
European Code of Conduct for Research Integrity.
Revised Edition. ALLEA. 2017. Revised Edition.
ALLEA. The applications section has some
mandatory words from previous contributions.
This research was completely done by the author,
the software, calculations, images, mathematical
propositions and statements, reference citations,
and text is original for the author. When a
mathematical statement, proposition or theorem
is presented, demonstration is always included.
The article is exclusively scientific, without any
commercial, institutional, academic, religious,
religious-similar, political, or economic influence.
When anything is taken from a source or previous
contribution, it is adequately recognized.[21,22]
AUTHOR’S BIOGRAPHY
Dr. Francisco Casesnoves earned the Engineering
and Natural Sciences PhD byTalllinn University of
Technology (started thesis in 2016, thesis defence/
PhD earned in December 2018, official graduate
Diploma 2019), and works in computational-
engineering/physics. Dr. Casesnoves currently
is independent research scientist. He earned
MSc-BSc, Physics/Applied-Mathematics (Public
Eastern-Finland-University, MSc Thesis in
Radiotherapy Treatment Planning Optimization,
which was developed after graduation in a series of
Radiation Therapy publications [2007-present]),
Graduate-with-MPhil, in Medicine and Surgery
(Public Madrid University Medicine School).
Casesnoves studied always in public-educational
institutions. Casesnoves resigned definitely to
his original nationality in 2020 for ideological,
and ethical-professional reasons, and does not
belong to Spain Kingdom anymore. His constant
service to International Scientific Community and
Estonian technological progress (2016-present)
commenced in 1985 with publications in
Medical Physics, with further specialization
in optimization methods in 1997 at Finland―
at the moment approximately 100 recognized
publications with approximately 62 DOI papers.
His main branch is Computational-mathematical
Nonlinear/Inverse Methods Optimization.
Casesnoves best-achievements are the Numerical
Reuleaux Method in dynamics and nonlinear-
optimization (books 2019–2020), the Graphical
and Interior Optimization Methods (2016-8),
the new Computational Dissection-Anatomical
Method, (2020) and invention of Forensic
Robotics (2020–2021). Dr Casesnoves scientific

service since 2016 to the Free and Independent
Republic of Estonia for technological development
(and also at Riga technical University, Power
Electrical and Electronics Department) is about
30 physics-engineering articles, two books series,
and 1 industrial radiotherapy project associated
to Europe Union EIT Health Program (Tartu
University, 2017).
REFERENCES
1. Panjabi M, White A. Clinical Biomechanics of the
Spine. Pennsylvania, United States: Lippincott; 1980.
2. Ben E, Gomez-OlivenciaA, Kramer P. Spinal Evolution.
Berlin, Germany: Springer; 2019.
3. Casesnoves F. Software programming with lumbar spine
cadaveric specimens for computational biomedical
applications. Int J Sci Res Comput Sci Eng Inform
Technol 2021;7:7-13.
4. Casesnoves F. The Numerical Reuleaux Method, a
Computational and Dynamical Base with Applications.
First Part. Moldova: LambertAcademic Publishing; 2019.
5. Casesnoves, F. Die Numerische Reuleaux-Methode
Rechnerische und Dynamische Grundlagen mit
Anwendungen (Erster Teil); Germany Sciencia Scripts:
2019; ISBN-13: 978-620-0-89560-8, ISBN-10:
6200895600.
6. Casesnoves F, Suzenkov A. Mathematical models in
biotribology with 2D-3D erosion integral-differential
model and computational-optimization/simulation
programming. Int J Sci Res Comput Sci Eng Inform
Technol 2017;2:329-56.
7. Casesnoves F. Mathematical Models and Optimization
of Erosion and Corrosion, Doctoral Thesis. Estonia:
Taltech University Press; 2018.
8. Casesnoves F. Computational simulations of vertebral
body for optimal instrumentation design. ASME J Med
Dev 2012;6:11.
9. Casesnoves F, Lawson J. An Optimization Method
for Anterior Vertebral Body Morphometry to Enhance
Surgical Devices, Lecture-Poster. San Diego CA, USA:
2008 SIAM Conference of Imaging Science; 2008.
10. Casesnoves F. Computational simulations of anterior
vertebral surface for statistical optimization in surgical
instrumentation design. In: ASME Peer-reviewed
Conference Paper and Poster. Minneapolis, MN, USA:
Proceedings of the 2010 Design of Medical Devices
Conference; 2010.
11. Casesnoves F. Spinal Biomechanics Mathematical
Model for Lumbar Intervertebral Ligaments.
Reno, Nevada, USA: 2011 SIAM Conference on
Computational Science and Engineering; 2011.
12. Casesnoves F. Applied inverse methods for optimal
geometrical-mechanical deformation of lumbar
artificial disks/implants with numerical reuleaux
method. 2D comparative simulations and formulation.
Comput Sci Appl 2015;2:1-10.
13. Casesnoves F. A Monte-Carlo optimization method
for the movement analysis of pseudo-rigid bodies.
In: 10th
SIAM Conference in Geometric Design and
Computing. Texas, San Antonio, USA: Contributed
Talk; 2007.
14. Casesnoves F. Applied inverse methods for
deformable solid dynamics/kinematics in numerical
reuleaux method (NRM). Int J Numer Methods and
Appl 2013;9:109-31. Peer-Reviewed International
Mathematical/Computation Journal Article. This
Article is Specially Innovative in Inverse Problems
Applications for Deformable Solids Kinematics/
Dynamics, Further Publications are Included in United
States Congress Library and Numerical Reuleaux
Method is Accepted by Scientific Community as an
Innovative Dynamics Method in Deformable Solids
with Mechanical, Biomechanical and Aerospace
Applications. New Applications of this Method will be
Probably Found Significantly in Future; 2013.
15. Casesnoves F. Nonlinear comparative optimization for
biomaterials wear in artificial implants technology. In:
Presented in Applied Chemistry and Materials Science
RTU2018 Conference Proceedings; 2018.
16. Casesnoves F. Applied inverse methods for optimal
deformation of lumbar artificial disk/implants with
numerical reuleaux method and 3D voxelization-
computational simulations. Am Inst Sci Biosci Bioeng
2015;1:94-105. Available from: http://www.aiscience.
org/journal/bio [Last accessed on 2015 Sep 26].
17. Casesnoves F. 3D Improved mathematical model for
lumbar intervertebral ligaments (LILs). In: Proceedings
SIAM Life Sciences Conference Joint to SIAM Annual
Conference San Diego; 2012. p. 25-7.
18. Darwin C. The Origin of Species. United States: Barnes
Noble Classics; 2004.
19. Todinov M. Reliability and Risk Models. New York,
United States: Wiley; 2005.
20. Rosen J, Hannaford B, Satava R. Surgical Robotics.
New York, United States: Wiley; 2011.
21. European Textbook on Ethics in Research. European
Commission, Directorate-General for Research.
Unit L3. Governance and Ethics. Maastricht,
Netherlands: European Research Area, Science and
Society, EUR 24452 EN;2020.
22. ALLEA. The European Code of Conduct for Research
Integrity. Maastricht, Netherlands: ALLEA; 2017.

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