The document discusses the Cervical Vertebral Maturation (CVM) method for assessing optimal treatment timing in dentofacial orthopedics. CVM uses the shape of cervical vertebrae on lateral cephalograms to determine skeletal maturity. There are 6 stages from pre-pubertal to post-pubertal. Treatment effects are greater if timed around pubertal growth spurts - Class II treatment works best including peak mandibular growth, while Class III and maxillary expansion work best before peak growth. Optimal timing depends on whether treatment aims to enhance or restrict mandibular growth versus alter the maxilla.