DD of AII.docx
- 1. Salmonellesis Shigellosis E.Coli Staph intox-n Botulism Intestinal Yersiniosis Entero patogenic Entero toxigenic Entero hemorragic Entero aggregative Entero invasive Etiology - Toxigenity - - -ve, motile Sal.entiritidis Sal. Typhymurium ,…. Endotoxin: fever, microcirculation failure, septic shock. Enterotoxin (cholera like toxin): act adenylatcyclase …. -ve, non motile, non capsulated Sh.Dysentr. Sh.Sonney Sh.Flexneri Epidemiology - Mechanism of transmission Anthropo- zoonotic disease F/O, contamin. food, Close contact Anthropo- zoonotic disease F/O, contamin. food, Close contact - Sourse of transmission Human with manifestation Carriers Animals, Birds(raw eggs) Human with manifestati on Carriers Animals, - Season Warm more common, but can be any season Warm more common, but can be any season
- 2. Pathogenesis Endotoxin: fever, microcirculation failure, septic shock. Enterotoxin (cholera like toxin): act-n adenylatcyclase, increase c-AMF, 2 mechanism : colonisatio n, invasion. Incubation Period (IP) 2-5 days, 3 d 4-7 5 d Clinic picture Gastroenteritis Nousea, vomiting, watery green diarrhea, no pain, no mucos, blood……… Enterocolitis- abd pain, Green stool nd mucos nd blood SIGMOID COLITIS INVASIVE DIARHEA BLOOD MUCUS HEMOCOLI TIS HIGH INTOX Complication Dehydratation Septic shock Diagnosis CBC- Stool microscopy Stool culture Treatment Gastroenteritis – self limited Supportive, ors/iv Enterocolilitis – AB(cypro, azitro, cef3) Rehydratation
- 3. ORS