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Clinical decision modeling for
n00bs: The absolute
minimum you NEED to know
Suranga Nath Kasthurirathne
What is a Decision Model?
An intellectual template for perceiving,
organizing, and managing the business logic
behind a business decision [1].
When applied to Computer science,
and explained in plain English,
A computer based system that predicts an
outcome or makes a decision
[1] Gottinger, H. W., & Weimann, P. (1992). Intelligent decision support systems. Decision Support
Systems, 8(4), 317-332.
Why do we care?
Decision models:
• Allow us to leverage existing silos of
information for valuable purposes
• Saves time
• Lets the computer (and not a human) do
extremely complicated thinking
• Is very cool and science-y.
Data
Decision
Decision
Data
Flaws, mistakes,
Individual perspectives
Decision
models
Classification
J48
Logistic
Regression
Etc. etc.
Clustering
EM
Simple
Kmeans
Classification Vs. Clustering
Decision
models
Classification
J48
Logistic
Regression
Etc. etc.
Clustering
EM
Simple
Kmeans
Classification Vs. Clustering
What we wont cover
• Clustering / unsupervised approaches
• How algorithms work
• How modeling tools work
How does a human being do it?
Case study: Dr. Jones selects students
for the masters program
What happens inside the reviewers
brain?
Criteria 1 Criteria 2 Criteria 3 Outcome
Mark TRUE FALSE FALSE Reject
Alex TRUE TRUE FALSE Accept
Sarah TRUE TRUE TRUE Accept
The reviewers brain is trained to watch out for
specific criteria.
So basically….
What can Dr. Jones do wrong?
• Selects wrong criteria
• Places emphasis on the wrong criteria
• Forgets
• Makes mistakes
• And what if Dr. Jones is doing this for the first
time?
How does a computer replicate this?
The computer;
• Obtains a data vector, just like our brain does
• ‘Trains’ itself on this vector (just like our brains
do)
• Delivers decisions based on this knowledge
(just like we do!)
Weka, R project etc.
Computers also share our weakness
• Over fitting
– An applicant has won 10 Nobel prizes
• Imbalance
– Applications for a postdoc position are mistakenly
sent to Dr. Jones
• Missing data
– A blank doesn’t mean zero. It means, “I don’t
know”
Computers have their advantages
• Feature selection
• Boosting unbalanced data
• Being very very impartial and unbiased
Since real life is always more
complicated…
• No binary outcome
– Accept, reject, waitlist, no scholarship, small
scholarship
• No binary criteria
– Excellent track record
– Meh track record
– Slightly impressed track record
– Incomplete
Performing decision modeling:
guidelines
• Know thyself, know thy data
• Have an ‘unquestionable’ gold standard
(outcome variable)
• Use an existing tool
• Get a statistician involved, EARLY
USE A TOOL
No, really…..
Thank you

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Decision Modelling for n00bs

  • 1. Clinical decision modeling for n00bs: The absolute minimum you NEED to know Suranga Nath Kasthurirathne
  • 2. What is a Decision Model? An intellectual template for perceiving, organizing, and managing the business logic behind a business decision [1]. When applied to Computer science, and explained in plain English, A computer based system that predicts an outcome or makes a decision [1] Gottinger, H. W., & Weimann, P. (1992). Intelligent decision support systems. Decision Support Systems, 8(4), 317-332.
  • 3. Why do we care? Decision models: • Allow us to leverage existing silos of information for valuable purposes • Saves time • Lets the computer (and not a human) do extremely complicated thinking • Is very cool and science-y.
  • 7. What we wont cover • Clustering / unsupervised approaches • How algorithms work • How modeling tools work
  • 8. How does a human being do it? Case study: Dr. Jones selects students for the masters program
  • 9. What happens inside the reviewers brain? Criteria 1 Criteria 2 Criteria 3 Outcome Mark TRUE FALSE FALSE Reject Alex TRUE TRUE FALSE Accept Sarah TRUE TRUE TRUE Accept The reviewers brain is trained to watch out for specific criteria. So basically….
  • 10. What can Dr. Jones do wrong? • Selects wrong criteria • Places emphasis on the wrong criteria • Forgets • Makes mistakes • And what if Dr. Jones is doing this for the first time?
  • 11. How does a computer replicate this? The computer; • Obtains a data vector, just like our brain does • ‘Trains’ itself on this vector (just like our brains do) • Delivers decisions based on this knowledge (just like we do!)
  • 13. Computers also share our weakness • Over fitting – An applicant has won 10 Nobel prizes • Imbalance – Applications for a postdoc position are mistakenly sent to Dr. Jones • Missing data – A blank doesn’t mean zero. It means, “I don’t know”
  • 14. Computers have their advantages • Feature selection • Boosting unbalanced data • Being very very impartial and unbiased
  • 15. Since real life is always more complicated… • No binary outcome – Accept, reject, waitlist, no scholarship, small scholarship • No binary criteria – Excellent track record – Meh track record – Slightly impressed track record – Incomplete
  • 16. Performing decision modeling: guidelines • Know thyself, know thy data • Have an ‘unquestionable’ gold standard (outcome variable) • Use an existing tool • Get a statistician involved, EARLY
  • 17. USE A TOOL No, really…..

Editor's Notes

  • #2: Two points: 1. lot of interdisciplinary students who don’t understand what decision modelling is (2) Want vs. need, economics
  • #3: What is a Decision Model? If so and so, then you make a decision
  • #11: What in red? Mistake that are secific to humans
  • #14: In statistics and machine learning, overfitting occurs when a statistical model describes random error or noise instead of the underlying relationship.