WebGL is a JavaScript API that allows 3D graphics in the browser without plugins. It is based on OpenGL ES 2.0 and uses shader programs to control the graphics pipeline. Developers can create a <canvas> element and use WebGL methods through the context to render 3D graphics. Popular JavaScript frameworks like Three.js, BabylonJS, and OSGJS make it easier to use WebGL by handling lower level details. While WebGL provides powerful 3D capabilities, browser and system compatibility can vary.