The document discusses designing for performance by making fewer HTTP requests, using a content delivery network (CDN), and setting expires headers to cache assets. It recommends combining and minifying CSS and JavaScript files, placing external assets on a CDN, and using far-future expires headers to cache assets for a long time. The document also stresses measuring performance, understanding bottlenecks, using technologies like memcached, optimizing server-side performance, and building a culture focused on performance.