This document proposes a scheme to solve the out-of-sequence problem that can occur when route optimization is supported in Proxy Mobile IPv6 (PMIPv6). The scheme uses additional packet sequence numbers and time information when the out-of-sequence problem occurs. The performance of the proposed scheme is evaluated using a reliable packet transmission testbed and is compared to existing RO-supported PMIPv6 and an out-of-sequence time period scheme. Experimental results show that the proposed scheme prevents most out-of-sequence problems by using sequence numbers, while also reducing buffering costs compared to other schemes.