Development of PLC based Transdermal Patch Evaluation System

International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395 -0056
Volume: 04 Issue: 07 | July -2017 www.irjet.net p-ISSN: 2395-0072
© 2017, IRJET | Impact Factor value: 5.181 | ISO 9001:2008 Certified Journal | Page 591
Development of PLC based Transdermal patch evaluation system
P.G student Supriya k. dabhade, Prof.D.D.Dighe
Department of Electronics & Telecomm Engineering Matoshri college of engineering and research centre,
Nasik, India
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Abstract - The paper describes the basic adhesion which
signify combination of all interfacial intermolecular
interactions where “practical adhesion “present forces & work
need to be disrupted of interfacial region to adhere the system
.there are many factors which influence practical adhesion and
basic adhesion is discussed. Basically thickness of adhesion
cannot be determined by common techniques for that ideal
practical adhesion test is outlined. Some of the adhesion
measurement techniques thin films, thickfilms, andcoastingare
discussed briefly, and references are made to the recentreviews
on this topic.
For the adherence all techniques are different while measuring
the adhesion. While measuring the adhesion involved
difficulties are highlighted, and the unresolved problems are
brought into sharper focus. Examination of failure surfaces
carried out using analytical tools to ascertain the locus at
failure is important to understand mechanism.
Key Words: programmable logic control, adhesion,
force, motor, load cell, peel, substrate, speed,
transdermal drug delivery.
1. Introduction
This system describes patch is peeled away from the
substrate peeling of patch test is mechanical test that has
been used to determine adhesion strength. In an evaluation
system patch that is bonded to substrate by adhesive layer is
pulled apart at same angle to the underlying substrate the
force needed to separate the adhered from the substrate. The
peeling force is basically an adhesion strength used for joint
design purposes, recently the peel force test also used by
pharmaceutical industries to identify strength of adhesion of
tds patch over the substrate & many studies have been
carried out to clarify & define the mechanism of adhesion
between the two dissimilar materials. This procedure is
repeated for five samples if the peeling force is out of range
product fails the test determine during development of
product & or statistical assessment of multiple product batch
over the product shell life. on the system we apply the force
on tds patch which is adhered to steel surface & it is pulled by
mechanical assembly of servomotor this forceismeasuredby
strain gauge, the transducer which convert mechanical force
into electrical signal plc based system will perform the
operation by the ladder programming &will display the
status on human interface panel.
2. Objective
Test method signifies permanence of adhesives & peel ability
of self–adhesive patches .so, this instrument checks the
adhesion strength of patches. In earlier days the adhesion
strength of patches is done manually due to which quality of
patches are reduced. Sometimes parameters of patches
changes due to manual testing. So, to improve quality of
patches our system develop innovative idea
1. This system improve quality Of transdermal
patch
2. To achieve speed , force , angel by this system
3. Literature review
In earlier days quality of patches is determined by manual
testing. Due to manual testing parameters of patches are
vary and degradation of quality of patches. So, we
introduced these “development of programmable logic
control based transdermal patch evaluation system” to
maintain quality of patches. This system performs 180°&
90° test for checking quality of patches.
4. Design Methodology
It includes requirement for the testing the samples , block
diagram and Utilization. Adhesion test acceptancerangeof
product is specific and should be defined generally that
adhesion of each patch is assure of transdermal drug
delivery system is within the range specified by the
product design and is consistent between batches on the
product development specifications or statistical
assessment of multiple product batches over theproduct’s
shelf life.
4.1 Facilities required
Test equipment: A tensile tester , capable of peeling a
laminate through an angle of 180 degree with a separate
jaw rate of 300mm per minute with an accuracy of 2%Test
plates made of float glass or similar plate glass, standard
test roller.
Test pieces: These should be strips taken from a
individual sample of material. The strips should be 25mm
wide and have a minimum length of 175mm in the
machine direction. The cuts should be clean and straight.
At least three strips should be taken from each material

sample. Test conditions temperature 23°C_2°C,
50%RH_5%RH. The test sample or least strips should be
conditioned for not less than 4 hours before testing.
4.2 Block Diagram
4.3 Utilization
1) PLC-
 High speed CPU module with greater expansions
 Eight input eight outputs
 Circuit breakers
 Flexi logic is compact plc
 Two serial ports
 One Ethernet port
 RISC processor is of 32 bit
 Easy ladder programming
2) HMI
 Digital input &output integrated
 Rated 24v DC
 Input connected to plc
 High speed Counter & timer
 IP65 design
 Feature with Alarms
 Ladder logic operated
 Future with PWM functionalities
5. Hardware section
5.1 PLC (programmable logic control)
Fig1.PLC module with HMI expansion
Also referred to as Programmable controllers they are
in computer family. Used in commercial and industrial
applications. A PLC accept the Inputs from HMI, makes
decisions by the ladder programming , and controls
Outputs.
5.2 HMI (human machine interface)
Fig 2.touch screen
The Human/Machine Interface is multi-function
descriptor is “versatility”.
The HMI has three modes of operation: Programmable
Display, Thumbwheel Emulation and Register. Modes
can be switched on-the-fly. Also have six programmable
function keys, 64 registers that store numerical, and
4kbytes of user storage. The HMI can beprogrammedby
using the included Graphic User Interface: The HMI
Screen Builder, or by using escape codes.
5.3 Sensor
Fig 3. S-type load cell
A load cell is a sensor that converts force pressure into
electronic signal. This signal may be a voltage change,
current change or frequency change thatdependsonthe
type of load cell and circuit used. Load cells use the
principle of change of resistance in response to an
applied load. This is termed piezo-resistive.

5.4 Motor
Fig 4.DC servo motor
The servo motor is assembly: a normal DC motor,a gear
reduction unit, a position-sensing device, and a control
circuit. Servo motor functions are to receive a control
signal that perform a desired output position of the
shaft, and apply power to motor until its shaft turns to
that position. It uses encoder at the feedback that
senses the position of the shaft; the servo has a 3 wire
connection: power, ground, and control. And has
continuous power source; the servo has its own drive
electronics that draw current from the power lead to
drive the motor.
6. Software Section
6.1 Flow Chart
7. Experimental set up
7.1 180° test
This is a quality control checking instrument for 180°
test Prepare the sample for test patch is cut using the
specimen cutter and the patch is adhered on test panel
with help of hand roller with even pressure Patch is
adhered to the test panel and test panel is place on the
slide bar and fixed with the jaw one end of the tds patch
is grip to the fixtures and command is processed to
motor through HMI with extension of PLC and patch is
peel away and force and speed displayed. When
command is processed slide bar slide in reverse
horizontal position
7.2 90° test
This is a quality control checking instrument for 90°test
Prepare the sample for test. Patch is cut using the
specimen cutter and the patch is adhered on test panel
with help of hand roller with even pressure Patch is
adhered on the test panel here fixture is adjusted
according to 90° angle by moving the jaw upward And
by fixing it slide bar plate is tilted 90° position test panel
is place on the slide bar and fixed with the jaw one end
of the tds patch is grip to the fixtures and command is
processed to motor through HMI with extension of PLC
and patch is peel away and force and speed displayed.
When command is processed slide bar slide in reverse
horizontal position

8. Conclusion
By the evaluation of the system we can monitor the
adhesion of patches and improve the quality of patches
by performing various test 180° and 90° test according
to American standard. and check theforceappliedonthe
patch i.e. when the patch is peeled away from the
substrate force recordedand displayedontheHMIpanel
similarly the HMI will display the ten sample interval
peak reading.
Acknowledgment
With the respect and gratitude, I like to thank everyone
who has helped us directly or indirectly for the
completion of this project work.
I express my heartily gratitude towards Prof.
Devidas D. Dighe for guiding us and also for his
encouragement to complete project work on
Development of PLCbasedtransdermal patchevaluation
system Sponsored by orchid Scientifics & Innovative
India PVT.LTD.
We are ending this acknowledgement with deep
indebtedness to our friends who have helped us.
REFERENCES
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3.https://books.google.co.in/books?id=awyRqCsgKeoC&
pg=PA33&lpg=PA33&dq=present+theories+of+peel+ad
hesion+tester&source=bl&ots=V1AxF_1pc7&sig=vE-
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il2cm0xqXRAhUZR48KHXGnDAQ4ChDoAQhFMAE#v=on
epage&q=present%20theories%20of%20peel%20adhes
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4.http://bdmlx.stanford.edu/twiki/pub/Rise/Adhesion
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5/Zhang_Thesis.pdf?sequence=2
8. https://studylib.net/doc/18042822/astm-tape-
adhesion-test---metal-roof-and-metal-siding-paint
9.http://oaktrust.library.tamu.edu/bitstream/handle/1
969.1/ETD-TAMU-2008-05-
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