DevOps and ITSM can work together in an enterprise by focusing on principles like improving flow, challenging ceremony, shifting left, making changes smaller and more frequent, automating processes, and embedding controls. While ITIL provides benefits like a service focus and resilience, it can be too sequential, siloed, and plan-centric. DevOps aims to be more adaptive by getting out of the way, treating products not projects, and accelerating delivery through practices like continuous testing and deployment. Both approaches need flexibility to evolve with new ways of working.