Different between MHC class1 and MHC class2
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The document outlines the differences between MHC class I and class II molecules, highlighting their occurrences, structures, functions, and genetic encoding. MHC class I is present on all nucleated cells and primarily clears endogenous antigens, while MHC class II is found on antigen-presenting cells and clears exogenous antigens. It details their structural composition, how they present antigens to T cells, and their respective chromosome locations.
Different between MHC class1 and MHC class2
- 1. Different between MHC class 1 and MHC class 2 Presented by M Kamil Khan Microbiologist
- 2. Content • Diagrammatically differences • Occurrences • Structures • Functions • Encoded chromosomes • Antigen-presenting Domains • Responsive Cells
- 4. 2. Occurrences • MHC Class I – They are found on all nucleated cell types in the body. • MHC Class II – They are found on antigen presenting cells like macrophages, dendritic cells, and B cells.
- 5. 3. Structures • MHC Class I – They consist of 3 alpha domains and 1 beta domain. • MHC Class II – They consist of 2 alpha and beta domains.
- 6. 4. Function • MHC Class I – Their main role is to clear endogenous antigens that comes from the cytoplasm • MHC Class II – Their main role is to clear exogenous antigens that comes outside the foreign organisms
- 7. 5. Encoded Chromosomes • MHC Class I – Alpha domains are found on the locus of chromosome 6. On the other hand, beta chains are found on chromosome 15. • MHC Class II – They are found on chromosome 6.
- 8. 6. Antigen-presenting Domains • MHC Class I – Both alpha 1 and 2 domains have something to do with the presentation of antigens in the molecules of MHC class I. • MHC Class II – Both alpha 1 and beta 2 domains have something to do with the presentation of antigen in MHC Class II molecules.
- 9. 7. Responsive Cells • MHC Class I – Present antigens to cytotoxic T cells by binding on CD8 receptor on cytotoxic T cell • MHC Class II – Present antigens to helper T cells by binding on CD4 receptor on helper T cell
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