Digestion of protein starts in the stomach. The stomach releases gastrin in response to food, which stimulates digestive juices including hydrochloric acid and the enzyme pepsinogen. Pepsinogen is converted to the active enzyme pepsin in the stomach, which breaks proteins down into polypeptides. The pancreas then secretes trypsinogen, chymotrypsinogen and other enzymes into the small intestine to further break down polypeptides into dipeptides, tripeptides and amino acids with the help of the intestinal enzyme peptidase.