The document outlines several major disadvantages of drug use. It discusses how heroin can cause high blood pressure, dental issues, constipation, and depression. Cocaine from coca leaves causes hyperactivity, depression, anxiety, and euphoria. Methamphetamine, also known as meth, increases excitement but can also lead to psychological disorders. Crack cocaine, which emerged in the 1980s, can cause nausea, overstimulation, and psychosis. Ecstasy increases confidence, awareness, and mental clarity but is often found in drug clubs and all drugs have researched side effects. The document recommends staying away from drugs regardless of type or perceived benefits due to these health risks.