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DISORDERS OF LEUCOCYTES
DR. AREEJ HAQUE
JR-2, PATHOLOGY
DEFINITIONS
• QUANTITATIVE DISORDERS – They are related to the concentration of leucocytes (leucocyte
counts) in peripheral blood.
• QUALITATIVE DISORDERS – They refer to the structural or functional abnormalities of white
blood cells.
• LEUCOCYTOSIS - It is defined as an increase in the number of circulating leucocytes (total
leucocyte count) above the upper level of normal.
• LEUCOPENIA - refers to total leucocyte count below the lower limit of normal.
• LEUKEMOID REACTION – It refers to the presence of markedly increased leucocyte count
(>50,000/cmm) and immature white blood cells in peripheral blood resembling leukaemia but
occurring in non-leukaemic conditions.
Disorders of leukocytes lecture and presentation
NEUTROPHILIA
• NEUTROPHILIA - Neutrophilia or neutrophilic leucocytosis is an increase in the
absolute neutrophil count above normal level (usually > 7,500/cmm).
NEUTROPENIA
• NEUTROPENIA – It refers to reduction in the number of neutrophils in the
peripheral blood below the normal level.
SHIFT TO LEFT
SHIFT TO LEFT: Increased percentage of immature
granulocytes in peripheral blood (usually up to bands
and metamyelocytes)

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Disorders of leukocytes lecture and presentation

  • 1. DISORDERS OF LEUCOCYTES DR. AREEJ HAQUE JR-2, PATHOLOGY
  • 2. DEFINITIONS • QUANTITATIVE DISORDERS – They are related to the concentration of leucocytes (leucocyte counts) in peripheral blood. • QUALITATIVE DISORDERS – They refer to the structural or functional abnormalities of white blood cells. • LEUCOCYTOSIS - It is defined as an increase in the number of circulating leucocytes (total leucocyte count) above the upper level of normal. • LEUCOPENIA - refers to total leucocyte count below the lower limit of normal. • LEUKEMOID REACTION – It refers to the presence of markedly increased leucocyte count (>50,000/cmm) and immature white blood cells in peripheral blood resembling leukaemia but occurring in non-leukaemic conditions.
  • 4. NEUTROPHILIA • NEUTROPHILIA - Neutrophilia or neutrophilic leucocytosis is an increase in the absolute neutrophil count above normal level (usually > 7,500/cmm).
  • 5. NEUTROPENIA • NEUTROPENIA – It refers to reduction in the number of neutrophils in the peripheral blood below the normal level.
  • 6. SHIFT TO LEFT SHIFT TO LEFT: Increased percentage of immature granulocytes in peripheral blood (usually up to bands and metamyelocytes)