This study aimed to optimize electrode positions for measuring facial electromyography (fEMG) signals using a 3D head model. A highly detailed 3D head model was developed from medical images and used to simulate fEMG signals from the frontalis and corrugator muscles. Various electrode positions on the forehead were tested to determine which positions provided the strongest signals and best separation of the two muscle activations. The results showed that electrode pairs measuring each muscle should be oriented orthogonally to best distinguish the muscle signals. The optimal positions found can help improve fEMG-based human-computer interfaces by providing more accurate muscle activation measurements from fewer electrodes.