This document discusses the need for a new approach to cybersecurity using machine learning and mathematics to deliver an "immune system for the enterprise." It argues the traditional approach of separating inside and outside has failed because threats are already inside complex networks and subtle human behaviors are difficult to detect. A new approach is needed to understand what is normal and identify subtle threats based on probabilities rather than rules. Insider threats are underestimated as employees and partners with access could intentionally or unintentionally help attackers. Ensuring data integrity beyond just preventing loss or theft is also key to protecting organizations.