The Agency for Healthcare Research and Quality (AHRQ) sponsors evidence reports and technology assessments to enhance healthcare quality in the U.S. through the Evidence-Based Practice Centers (EPCs), focusing on the patient-centered medical home (PCMH) model that aims to improve primary care and patient experiences. Despite the potential benefits of PCMH interventions, the evidence supporting their effectiveness is uncertain, prompting this systematic review to evaluate ongoing and completed studies regarding PCMH outcomes. The review seeks to identify knowledge gaps and promote further research on comprehensive PCMH implementations.