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Presented By:
Dr Sumeet Kaur
INTRODUCTION
TYPES
MATERNAL INHERITANCE
ORGANELLAR INHERITANCE
INHERITANCE INVOLVING INFECTIOUS
PARTICLES
EVOLUTIONARY SIGNIFICANCE OF
ORGANELLES
SIGNIFANCE OF EXTRANUCLEAR
INHERITANCE
INTRODUCTION
 Extra chromosomal inheritance defined as non-
mendelian inheritance, usually involving DNA in
replicating mitochondria and some other organelles of
cell.
 Commonly defined as transmission through cytoplasm
rather than nucleus.
 Inheritance due to genes located in cytoplasm (plasma
genes)
 Plasma genes are located in DNA present in
mitochondria and in chloroplast.
 Together both the DNAs are called organelle DNA.
EXTRANUCLEAR INHERITANCE IS
OF THREE TYPES :
Maternal inheritance
Organellar inheritance
Inheritance involving infectious
particles
MATERNAL INHERITANCE
 character of only one of the two parents is
transmitted to the progeny .
 In most animals, parental mitochondria
enter the oocyte cytoplasm after fertilization
their mt.dna is never transmitted to the
offspring.
Two types of coiling pattern
EXAMPLE : SHELL COILING IN
SNAIL(Lymnea peregra)
Right handed Left handed (sinistral or
anticlockwise)
(Dextral or
clockwise)
Dextral coiling female Dextral coiling male
DD dd
All dextral
DD Dd
Dd dd
D d
D
d
Phenotypic ratio 3:1
IN RECIPROCAL CROSS:
Sinistral coiling female Dextral coiling male
First generation : all sinisteral type
Other generation: 3 sinistral: 1 dextral
ORGANELLAR INHERITANCE
CHLOROPLAST
MITOCHONDRIA
CHLOROPLAST INHERITANCE
Specialized organelle found in higher plants.
Two membranes: outer and inner membrane.
It possess internal membrane in the form of flattened
sacs known as thyllakoids.
They form stalk of disc at some places known as grana.
Chloroplast has three parts:
 Envelope
 Matrix
 thyllakoids
extra-chromosomal-inheritance[1].pptx.pdfpdf
 Photosynthesis
Oxygen supply
Starch storage
Utilize carbondioxide
Synthesis of organic acid
Change into chromoplast
Food supply
GENOMIC STRUCTURE OF CHLOROPLAST DNA
 it resemble large bacterial plasmid or
small chromosomes.
 cpDNA is closed circular ds molecule.
 For example in MAIZE there are about 50
copies of DNA per chloroplast.
 Single chloroplast contain information of
126 different protein molecule.
 The complete sequence of cpDNA found
in liverworts and tobacco.
Examples of cpDNA
IN Mirabilis jalapa
(a) female branch × male branch
(green) (variegated)
Green plants only
(b) female branch × male branch
(variegated) (green)
Variegated plants only
DISTINGUISHING FEATURES OF CHLOROPLAST
AND NUCLEAR DNA
 cpDNA is circular while nuclear DNA is linear.
 Histone and other proteins are complexed with
nuclear DNA but not with cpDNA.
 After denaturation cpDNA reassociate much more
rapidly than nuclear DNA.
 cpDNA is smaller in size than nuclear DNA.
 Formation of D loop.
STRUCTURE OF MITOCHONDRIA
 Powerhouse of the cell.
 Position depends upon the
requirement of energy and
amino acid.
 it consist of three parts:
o outer and inner membrane
o Cristae
o matrix
FUNCTIONS OF MITOCHONDRIA
Store and release calcium .
Main seat of cell respiration.
Synthesis of amino acid(glutamic and aspartic acid).
Take part in maternal inheritance.
Synthesis of several biochemicals like chlorophyll,
cytochrome, alkaloid.
GENOMIC CHARACTER OF MITOCHONDRIAL DNA
 Mt.DNA is small genome
 it contain their own DNA which may be circular or
linear.
 Haploid in nature
 Mt.DNA contain 37 genes and enclosed two types of
rRNA and 22tRNA.
 G+C content of mt.DNA show variation from one sp. to
another.
 example: 18% in yeast ,47%in higher plants.
 Two region: coding region and central region .
extra-chromosomal-inheritance[1].pptx.pdfpdf
MATERNAL INHERITANCE OF MITOCHONDRIAL DNA
 During fertilization, sperm
only contribute its nucleus .
 mitochondria of the sperm
cell are located at the
mitochondrial sheath which is
destroyed upon fertilization.
 Only available mt.DNA is that
of the mother.
MITOCHONDRIA IN HUMAN
DISEASE
1. Laber’s herediatary optic nuropathy (LHON)
 Sudden onset of blindness in adult which is
associated with death of optic nerve due to mutation
in any of several mt.DNA.
 Net effect of these mutation has reductive efficiency
of oxidative phosphorylation to such extent that the
function of optic nerve is destroy which result in
total blindness.
 LHON show only maternal transmission.
2. Pearson marrow- pancreas syndrome(PMPS)
 It is also caused by mt.DNA in this disease there is loss
of bone marrow cell and this is fatal.
 Parents of person affected by the syndrome are almost
normal. i.e. that mutation (deletion) in mt.DNA
occurs either during oogenesis or during the
development of fet0us.
DISTINGUISHING FEATURES OF
NUCLEAR DNA AND Mt.DNA
NUCLEAR DNA MITOCHONDRIAL DNA
 Found in nuclear of cell.
 Bounded by nuclear
envelope.
 Two sets of 23 chromosome.
 Maternal and paternal
inheritance.
 Double helix.
 DNA packed into chromatin.
 Found in mt. of cell.
 No nuclear envelope.
 Several copies of the single
mt. DNA.
 Maternal inheritance only.
 Circular.
 Not packed in chromatin.
CYTOPLASMIC MALE STERILITY
 Progeny from cytoplasmic male sterility and a
normal male fertile strain and are all male sterile.
 it show cytoplasmic inheritance.
 As a result CMS strain has to be pollinated by male
fertile strain in every generation for its
maintainence.
 CMS is used in hybrid seed production in crops
like maize, jawar ,bajra etc.
EVOLUTIONARY SIGNIFICANCE OF
ORGANELLES
 The mitochondria and chloroplast once free
living bacteria that form symbiotic
relationships with the primitive eukaryotic
cell more than one billion years ago is
referred as endosymbiotic theory.
INHERITANCE INVOLVING
INFECTIOUS PARTICLE
 Non mendelian inheritance is associated with
infective particles like parasite, viruses.
 EXAMPLE: kappa particles in paramecium.
 T.M. sonneborn described the inheritance in
paramecium aurelia.
 There are two strains of paramecium : killer and
sensitive.
 Killer strain produce a toxic substance called
paramecin that is lethal to other individual called
sensitive.
extra-chromosomal-inheritance[1].pptx.pdfpdf
SIGNIFICANCE OF EXTRANUCLEAR
INHERITANCE
Role of various cytoplasmic organelles in different
organism.
Mapping of chloroplast and mitochondrial in several
species viz. yeasts, maize, human etc.
Easily transfer to agronomic bases for their use in
development of superior hybrids.
Role of mitochondria in the menifestation of hetrosis.
It leads to generation of new variants (ornamental
plant).
extra-chromosomal-inheritance[1].pptx.pdfpdf

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extra-chromosomal-inheritance[1].pptx.pdfpdf

  • 2. INTRODUCTION TYPES MATERNAL INHERITANCE ORGANELLAR INHERITANCE INHERITANCE INVOLVING INFECTIOUS PARTICLES EVOLUTIONARY SIGNIFICANCE OF ORGANELLES SIGNIFANCE OF EXTRANUCLEAR INHERITANCE
  • 3. INTRODUCTION  Extra chromosomal inheritance defined as non- mendelian inheritance, usually involving DNA in replicating mitochondria and some other organelles of cell.  Commonly defined as transmission through cytoplasm rather than nucleus.  Inheritance due to genes located in cytoplasm (plasma genes)  Plasma genes are located in DNA present in mitochondria and in chloroplast.  Together both the DNAs are called organelle DNA.
  • 4. EXTRANUCLEAR INHERITANCE IS OF THREE TYPES : Maternal inheritance Organellar inheritance Inheritance involving infectious particles
  • 5. MATERNAL INHERITANCE  character of only one of the two parents is transmitted to the progeny .  In most animals, parental mitochondria enter the oocyte cytoplasm after fertilization their mt.dna is never transmitted to the offspring.
  • 6. Two types of coiling pattern EXAMPLE : SHELL COILING IN SNAIL(Lymnea peregra) Right handed Left handed (sinistral or anticlockwise) (Dextral or clockwise) Dextral coiling female Dextral coiling male DD dd All dextral DD Dd Dd dd D d D d Phenotypic ratio 3:1
  • 7. IN RECIPROCAL CROSS: Sinistral coiling female Dextral coiling male First generation : all sinisteral type Other generation: 3 sinistral: 1 dextral
  • 9. CHLOROPLAST INHERITANCE Specialized organelle found in higher plants. Two membranes: outer and inner membrane. It possess internal membrane in the form of flattened sacs known as thyllakoids. They form stalk of disc at some places known as grana. Chloroplast has three parts:  Envelope  Matrix  thyllakoids
  • 11.  Photosynthesis Oxygen supply Starch storage Utilize carbondioxide Synthesis of organic acid Change into chromoplast Food supply
  • 12. GENOMIC STRUCTURE OF CHLOROPLAST DNA  it resemble large bacterial plasmid or small chromosomes.  cpDNA is closed circular ds molecule.  For example in MAIZE there are about 50 copies of DNA per chloroplast.  Single chloroplast contain information of 126 different protein molecule.  The complete sequence of cpDNA found in liverworts and tobacco.
  • 13. Examples of cpDNA IN Mirabilis jalapa (a) female branch × male branch (green) (variegated) Green plants only (b) female branch × male branch (variegated) (green) Variegated plants only
  • 14. DISTINGUISHING FEATURES OF CHLOROPLAST AND NUCLEAR DNA  cpDNA is circular while nuclear DNA is linear.  Histone and other proteins are complexed with nuclear DNA but not with cpDNA.  After denaturation cpDNA reassociate much more rapidly than nuclear DNA.  cpDNA is smaller in size than nuclear DNA.  Formation of D loop.
  • 15. STRUCTURE OF MITOCHONDRIA  Powerhouse of the cell.  Position depends upon the requirement of energy and amino acid.  it consist of three parts: o outer and inner membrane o Cristae o matrix
  • 16. FUNCTIONS OF MITOCHONDRIA Store and release calcium . Main seat of cell respiration. Synthesis of amino acid(glutamic and aspartic acid). Take part in maternal inheritance. Synthesis of several biochemicals like chlorophyll, cytochrome, alkaloid.
  • 17. GENOMIC CHARACTER OF MITOCHONDRIAL DNA  Mt.DNA is small genome  it contain their own DNA which may be circular or linear.  Haploid in nature  Mt.DNA contain 37 genes and enclosed two types of rRNA and 22tRNA.  G+C content of mt.DNA show variation from one sp. to another.  example: 18% in yeast ,47%in higher plants.  Two region: coding region and central region .
  • 19. MATERNAL INHERITANCE OF MITOCHONDRIAL DNA  During fertilization, sperm only contribute its nucleus .  mitochondria of the sperm cell are located at the mitochondrial sheath which is destroyed upon fertilization.  Only available mt.DNA is that of the mother.
  • 20. MITOCHONDRIA IN HUMAN DISEASE 1. Laber’s herediatary optic nuropathy (LHON)  Sudden onset of blindness in adult which is associated with death of optic nerve due to mutation in any of several mt.DNA.  Net effect of these mutation has reductive efficiency of oxidative phosphorylation to such extent that the function of optic nerve is destroy which result in total blindness.  LHON show only maternal transmission.
  • 21. 2. Pearson marrow- pancreas syndrome(PMPS)  It is also caused by mt.DNA in this disease there is loss of bone marrow cell and this is fatal.  Parents of person affected by the syndrome are almost normal. i.e. that mutation (deletion) in mt.DNA occurs either during oogenesis or during the development of fet0us.
  • 22. DISTINGUISHING FEATURES OF NUCLEAR DNA AND Mt.DNA NUCLEAR DNA MITOCHONDRIAL DNA  Found in nuclear of cell.  Bounded by nuclear envelope.  Two sets of 23 chromosome.  Maternal and paternal inheritance.  Double helix.  DNA packed into chromatin.  Found in mt. of cell.  No nuclear envelope.  Several copies of the single mt. DNA.  Maternal inheritance only.  Circular.  Not packed in chromatin.
  • 23. CYTOPLASMIC MALE STERILITY  Progeny from cytoplasmic male sterility and a normal male fertile strain and are all male sterile.  it show cytoplasmic inheritance.  As a result CMS strain has to be pollinated by male fertile strain in every generation for its maintainence.  CMS is used in hybrid seed production in crops like maize, jawar ,bajra etc.
  • 24. EVOLUTIONARY SIGNIFICANCE OF ORGANELLES  The mitochondria and chloroplast once free living bacteria that form symbiotic relationships with the primitive eukaryotic cell more than one billion years ago is referred as endosymbiotic theory.
  • 25. INHERITANCE INVOLVING INFECTIOUS PARTICLE  Non mendelian inheritance is associated with infective particles like parasite, viruses.  EXAMPLE: kappa particles in paramecium.  T.M. sonneborn described the inheritance in paramecium aurelia.  There are two strains of paramecium : killer and sensitive.  Killer strain produce a toxic substance called paramecin that is lethal to other individual called sensitive.
  • 27. SIGNIFICANCE OF EXTRANUCLEAR INHERITANCE Role of various cytoplasmic organelles in different organism. Mapping of chloroplast and mitochondrial in several species viz. yeasts, maize, human etc. Easily transfer to agronomic bases for their use in development of superior hybrids. Role of mitochondria in the menifestation of hetrosis. It leads to generation of new variants (ornamental plant).