This document discusses extrusion and spheronization processes used in pharmaceutical manufacturing. Extrusion forces material through a die to create desired shapes, while spheronization forms small spheres between 0.5-10mm in diameter. Key advantages of spheres include optimal flow, reproducible packing, minimum surface area, and ability to easily coat for controlled release. The process involves mixing, extruding through a screw or basket extruder to form extrudates, spheronizing using a rotating friction plate to form spheres, and optional coating. Key factors that affect spheronization include disc speed and load, groove geometry, product properties, and retention time. Various sized extruders and spheronizers are described for