Fading and the Doppler effect can impact wireless communication. Fading occurs when multipath signals interfere, causing fluctuations in signal strength over time. The Doppler effect is the change in frequency of a wave due to relative motion between the source and observer. In wireless communication, the Doppler effect causes shifts in the received carrier frequency due to motion between the transmitter and receiver. This Doppler spread must be accounted for in system design through techniques like Doppler compensation.