Friability test ppt

Friable: “ A friable substance is any substance that can be reduced to finer particles by the action of a small pressure or friction, such as rubbing or inadvertently brushing up against the substance”. Friability test: Defined as the % of weight loss by tablets due to mechanical action during the test. Tablets are weighing before & after testing & friability is expressed as a percentage loss on pre-test tablet weight. & Friability test is done to check the ability of the compressed tablet to avoid fracture & breaking during the transport. This testing involves repeatedly dropping a sample of tablets over a fixed time, using a rotating wheel with a baffle. The result is inspected for broken tablets, and the percentage of tablet mass lost through chipping. If the average weight of the tablet is 0.65gm or less. Take 10 times of the whole weight i.e., 6.5 gm 2. Carefully deducts the tablets & weight required numbers of tablets. Initial weight = 6.536gm 3. Set the Time duration for 4min 4. Set number of counts to 100 5. Make sure the drum is cleaned with no contaminates , add the initial weighted tables carefully & close the lid 6. Click Start button Drum diameter : 283 -291mm Depth: 36-40mm Inner radius of the curve projection : 75.5mm – 85.5mm Outer diameter of the central ring : 24.5mm – 25.5mm Rotation Speed : 25 +/_ 1 cycle Time Set: 4 min After 4min automatically it stops , 7. Take out the tablets & take out the dust from the tablets using brush /crumps 8. Take the After weight of the tablets Total weight of after rotation= 6.443gm Interpretation : Value of friability should not be more than 1% for most of tablets. If the value of friability for the first is greater than 1%, then repeat the test twice & mean of three values is taken. If the mean value of three tests is less than 1% tablets passes the friability test, otherwise tablet fails the test. If the tablets are broken , chipped or cracked during the test, the tablets fails the friability test. By ArcImBioCLinica (AIBC)