The document presents a conceptual framework for delivering improvements in healthcare developed by the NIHR CLAHRC for Northwest London. It identifies 12 objectives across 3 perspectives that must be considered: what improvements should be made, where and who is involved in improvements, and how improvements should take place. It emphasizes understanding existing knowledge, producing new knowledge through research, and iterative development through active engagement and understanding variation. The framework recognizes the complexity of healthcare systems and the need for transdisciplinary work and multiple perspectives. It provides implications for moving the research agenda to understanding how improvements work in practice and the necessity of its counter-cultural approach.