The document provides an overview of substance use disorders and evidence-based practices for treatment. It notes that 149-272 million people globally used illicit substances in 2009, but only 12-30% of those with substance use disorders receive treatment. Evidence-based practices, which are supported by scientific research, clinical expertise, and feasibility, have been shown to improve treatment outcomes. The document reviews global substance use issues, evidence-based practices that are recommended, and practices that are not recommended.