Uganda has a high prevalence of HIV but lacks widespread knowledge of HIV status due to issues with traditional testing methods, such as lack of privacy and stigma. HIV self-testing (HIVST) has the potential to increase testing rates in Uganda by addressing these issues. However, considerations must be made around legal and policy frameworks to allow oral fluid rapid diagnostic tests and counseling other than in-person. Leadership from the Ministry of Health will also be needed to ensure quality assurance, supply chain management, and linkage to care for those testing positive through HIVST.