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HOW DID IT ALL START ?
DR. MOHAMMAD ABBAS
Assistant Professor
& Orthopedic Consultant
Faculty of Medicine
King Abdulaziz University
NOVEMBER 2009
 KNEE COURSE BY SMITH & NEPHEW IN TOURS,
FRANCE.
 THE TRUFIT PLUG FOR FOCAL CHONDRAL
DEFECT WAS INTRODUCED BY DANIEL SARIS
FOR FOCAL CHONDRAL DEFECT
TRUFIT PLUG
MSCs
? FOR LARGER AREA OF CARTILAGE DEGENERATION
? TOTAL OSTEOARTHRITIS
TRUFIT PLUG
JANUARY 2010
THE IDEA AND PROCESS OF
STARTING A SCIENTIFIC CHAIR
THROUGH RACI @ KAU
A long tedious process to fulfill
the RACI requirements
 Sponsor.
 Distinguished stem cell professor.
 3 years detailed plan.
 Organizational chart.
 Web page.
“ There is a huge gap between
clinicians and scientists ”
Building up the team
Stem cells ProfessorMolecular hematologist
Building up the team
 Biochemistry professor.
 Consultant Hematologist
 Consultant Radiologist.
 PhD scientist in stem cell biology
 Orthopedic surgeons.
 Lab. specialist with
master in tissue culture.
Building up the team
‫الكرسي‬ ‫مشـــرف‬
‫د‬.‫عباس‬ ‫محمد‬
‫الكرسي‬ ‫أستـاذ‬‫الكرسي‬ ‫أعضاء‬‫البحثية‬ ‫المجموعات‬
‫الخاليا‬ ‫مختبر‬
‫الجذعية‬
‫المالية‬ ‫اإلدارة‬
‫ا‬.‫د‬.‫كافينا‬ ‫وائل‬‫د‬.‫السايس‬ ‫فاتن‬
‫أ‬.‫د‬.‫قاري‬ ‫ممدوح‬
‫أ‬.‫د‬.‫عطا‬ ‫حازم‬
‫د‬.‫الكاف‬ ‫محمد‬
‫أبحاث‬ ‫مجموعة‬
‫العظام‬
‫د‬.‫عباس‬ ‫محمد‬
‫د‬.‫شودري‬ ‫علي‬
‫د‬.‫درويش‬ ‫حسام‬
‫د‬.‫حمدي‬ ‫عمرو‬
‫د‬.‫الكاف‬ ‫محمد‬
‫أبحاث‬ ‫مجموعة‬
‫الدم‬ ‫أمراض‬
‫د‬.‫السايس‬ ‫فاتن‬
‫أ‬.‫د‬.‫قاري‬ ‫ممدوح‬
‫د‬.‫جوثمان‬ ‫كالميجام‬
‫أ‬.‫السهلي‬ ‫حنين‬
‫األشعة‬ ‫أبحاث‬ ‫مجموعة‬
‫د‬.‫قطب‬ ‫ممدوح‬
‫الكيمياء‬ ‫أبحاث‬ ‫مجموعة‬
‫الحيوية‬
‫أ‬.‫د‬.‫عطا‬ ‫حازم‬
‫أ‬.‫د‬.‫قاري‬ ‫ممدوح‬
‫د‬.‫جوثمان‬ ‫كالميجام‬
‫أ‬.‫النونو‬ ‫رهام‬
‫أ‬.‫السهلي‬ ‫حنين‬
‫مع‬ ‫بالتعاون‬
‫البحوث‬ ‫مركز‬
‫واالستشارات‬
Organizational chart
How did it all start
3 years detailed plan
Inauguration was on 22 Feb. 2012.
How did it all start
ESTABLISHING THE
STEM CELL LAB. IN THE
OPRATING THEATRE
Establishing a stem cells
unit in CEGMR in KFRMC
Isolation & characterization of MSCs
Team members
are regularly
attending ICRS
world congress
2015
2013
2012
Team Development
Participation in ICRS courses
 Radiologist  MRI T2
mapping of cartilage
course in Vienna 2012.
 Orthopedic surgeons
 learning surgical
procedures for cartilage
regeneration.
Team Development
1- Isolation and Characterization of
Mesenchymal Stem Cells from Bone Marrow
of Osteoarthritis patients
2- Epigenetic analysis of osteoarthritis
patients
3- Exome sequence analysis for osteoarthritis
patients
4- Evaluation of ex-vivo cartilage regeneration
with mesenchymal stem cells derived from
the human bone marrow (hBM-MSCs) and
synovial fluid (hSF MSCs) from osteoarthritis
patients
Molecular Hematology Research
1- EFFECT OF ADRENALINE & VOLTAREN
ON VIABILITY and PROLIFERATION of
HUMAN MESENCHYMAL STEM CELLS
2- EFFECT OF MARCAINE &
DEXAMETHASONE ON VIABILITY and
PROLIFERATION of HUMAN
MESENCHYMAL STEM CELLS
0
0.2
0.4
Control Adrenaline
100ug/ml
Adrenaline
300ug/ml
OD
Effect of Adrenaline on the
Viability and Proliferation
of Human MSCs
Mean
0
0.1
0.2
0.3
OD
Effect of Marcaine on the
viability and proliferation
of human MSCs
Mean
Biochemistry Research
The focus was on building
up Articular Cartilage
Orthopedic Animal Research
Two projects done on
rabbits for focal defects
Orthopedic Animal Research
Most recent research
focuses on Induced Total
Surgical Arthritis in Rabbits
using
 MSCs + Scaffolds
Orthopedic Animal Research
 6 monthly report
 A yearly presentation to RACI
committee
 A yearly financial report
Fulfilling RACI follow up
A yearly meeting with the sponsor
PLEASE VISIT OUR WEB PAGE

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How did it all start

  • 1. HOW DID IT ALL START ? DR. MOHAMMAD ABBAS Assistant Professor & Orthopedic Consultant Faculty of Medicine King Abdulaziz University
  • 2. NOVEMBER 2009  KNEE COURSE BY SMITH & NEPHEW IN TOURS, FRANCE.  THE TRUFIT PLUG FOR FOCAL CHONDRAL DEFECT WAS INTRODUCED BY DANIEL SARIS
  • 3. FOR FOCAL CHONDRAL DEFECT TRUFIT PLUG
  • 4. MSCs ? FOR LARGER AREA OF CARTILAGE DEGENERATION ? TOTAL OSTEOARTHRITIS TRUFIT PLUG
  • 5. JANUARY 2010 THE IDEA AND PROCESS OF STARTING A SCIENTIFIC CHAIR THROUGH RACI @ KAU
  • 6. A long tedious process to fulfill the RACI requirements  Sponsor.  Distinguished stem cell professor.  3 years detailed plan.  Organizational chart.  Web page.
  • 7. “ There is a huge gap between clinicians and scientists ” Building up the team
  • 8. Stem cells ProfessorMolecular hematologist Building up the team
  • 9.  Biochemistry professor.  Consultant Hematologist  Consultant Radiologist.  PhD scientist in stem cell biology  Orthopedic surgeons.  Lab. specialist with master in tissue culture. Building up the team
  • 10. ‫الكرسي‬ ‫مشـــرف‬ ‫د‬.‫عباس‬ ‫محمد‬ ‫الكرسي‬ ‫أستـاذ‬‫الكرسي‬ ‫أعضاء‬‫البحثية‬ ‫المجموعات‬ ‫الخاليا‬ ‫مختبر‬ ‫الجذعية‬ ‫المالية‬ ‫اإلدارة‬ ‫ا‬.‫د‬.‫كافينا‬ ‫وائل‬‫د‬.‫السايس‬ ‫فاتن‬ ‫أ‬.‫د‬.‫قاري‬ ‫ممدوح‬ ‫أ‬.‫د‬.‫عطا‬ ‫حازم‬ ‫د‬.‫الكاف‬ ‫محمد‬ ‫أبحاث‬ ‫مجموعة‬ ‫العظام‬ ‫د‬.‫عباس‬ ‫محمد‬ ‫د‬.‫شودري‬ ‫علي‬ ‫د‬.‫درويش‬ ‫حسام‬ ‫د‬.‫حمدي‬ ‫عمرو‬ ‫د‬.‫الكاف‬ ‫محمد‬ ‫أبحاث‬ ‫مجموعة‬ ‫الدم‬ ‫أمراض‬ ‫د‬.‫السايس‬ ‫فاتن‬ ‫أ‬.‫د‬.‫قاري‬ ‫ممدوح‬ ‫د‬.‫جوثمان‬ ‫كالميجام‬ ‫أ‬.‫السهلي‬ ‫حنين‬ ‫األشعة‬ ‫أبحاث‬ ‫مجموعة‬ ‫د‬.‫قطب‬ ‫ممدوح‬ ‫الكيمياء‬ ‫أبحاث‬ ‫مجموعة‬ ‫الحيوية‬ ‫أ‬.‫د‬.‫عطا‬ ‫حازم‬ ‫أ‬.‫د‬.‫قاري‬ ‫ممدوح‬ ‫د‬.‫جوثمان‬ ‫كالميجام‬ ‫أ‬.‫النونو‬ ‫رهام‬ ‫أ‬.‫السهلي‬ ‫حنين‬ ‫مع‬ ‫بالتعاون‬ ‫البحوث‬ ‫مركز‬ ‫واالستشارات‬ Organizational chart
  • 13. Inauguration was on 22 Feb. 2012.
  • 15. ESTABLISHING THE STEM CELL LAB. IN THE OPRATING THEATRE
  • 16. Establishing a stem cells unit in CEGMR in KFRMC
  • 18. Team members are regularly attending ICRS world congress 2015 2013 2012 Team Development
  • 19. Participation in ICRS courses  Radiologist  MRI T2 mapping of cartilage course in Vienna 2012.  Orthopedic surgeons  learning surgical procedures for cartilage regeneration. Team Development
  • 20. 1- Isolation and Characterization of Mesenchymal Stem Cells from Bone Marrow of Osteoarthritis patients 2- Epigenetic analysis of osteoarthritis patients 3- Exome sequence analysis for osteoarthritis patients 4- Evaluation of ex-vivo cartilage regeneration with mesenchymal stem cells derived from the human bone marrow (hBM-MSCs) and synovial fluid (hSF MSCs) from osteoarthritis patients Molecular Hematology Research
  • 21. 1- EFFECT OF ADRENALINE & VOLTAREN ON VIABILITY and PROLIFERATION of HUMAN MESENCHYMAL STEM CELLS 2- EFFECT OF MARCAINE & DEXAMETHASONE ON VIABILITY and PROLIFERATION of HUMAN MESENCHYMAL STEM CELLS 0 0.2 0.4 Control Adrenaline 100ug/ml Adrenaline 300ug/ml OD Effect of Adrenaline on the Viability and Proliferation of Human MSCs Mean 0 0.1 0.2 0.3 OD Effect of Marcaine on the viability and proliferation of human MSCs Mean Biochemistry Research
  • 22. The focus was on building up Articular Cartilage Orthopedic Animal Research
  • 23. Two projects done on rabbits for focal defects Orthopedic Animal Research
  • 24. Most recent research focuses on Induced Total Surgical Arthritis in Rabbits using  MSCs + Scaffolds Orthopedic Animal Research
  • 25.  6 monthly report  A yearly presentation to RACI committee  A yearly financial report Fulfilling RACI follow up
  • 26. A yearly meeting with the sponsor
  • 27. PLEASE VISIT OUR WEB PAGE

Editor's Notes

  • #9: صور لممدوح
  • #14: Clear pic
  • #17: صورة الابحاث
  • #18: Pic isolation 7-2
  • #21: Review by dr abbas