The document summarizes research on developing human-centered AI systems that support end-users. It discusses explaining model outcomes to increase trust, enabling user interaction with explanations, and identifying what end-users need through evaluations. Strategies discussed include data-centric explanations, in-situ decision support, explaining model behavior, and addressing different needs in high-stakes domains like healthcare. The goal is developing explanations and interfaces tailored to non-experts through user-centered design and evaluations.