Hydrocephalus can be caused by closure of meningomyelocele, congenital aqueductal stenosis, or intraventricular hemorrhage in neonates. Clinical presentations include lethargy, vomiting, and cardio respiratory problems. For anesthesia, rapid sequence induction is preferred to avoid increases in intracranial pressure during intubation or crying. Volatile anesthetics, opioids, and nitrous oxide are not contraindicated due to open cranial sutures blunting pressure increases in neonates. Extubation depends on any intraoperative apnea or bradycardia. Surgical management involves placement of a ventriculo-peritoneal shunt.