This document provides an introduction to infection prevention and control (IPC) in healthcare settings. It defines IPC and healthcare-associated infections (HAIs), describes the historical evolution of IPC practices from Semmelweis to the present, and outlines current IPC structures and practices. These include standard and additional precautions to prevent transmission, as well as national, county, and facility-level coordination of IPC programs according to Kenyan guidelines. The overall benefits of adhering to IPC practices are also highlighted.