This document summarizes a workshop on InfoSymbiotic/DDDAS systems. It describes InfoSymbiotic/DDDAS as a paradigm that unifies computational models with real-time data acquisition and control. Recent technological advances have increased opportunities for this approach. The workshop brought together over 100 participants to discuss research opportunities in applications, algorithms, systems software, instrumentation, and cyberinfrastructure to advance the field. It calls for increased support for multidisciplinary InfoSymbiotic/DDDAS research to enable transformative impacts.