The lecture on instrumental variables and control functions focuses on advanced econometric techniques for addressing endogeneity in public policy evaluation, particularly through two-stage least squares (2SLS) and control functions. It discusses the importance of identifying valid instruments that meet exclusion restrictions and explores their application in case studies, such as the relationship between schooling and wages. Additionally, it highlights common issues and misconceptions associated with 2SLS methods, as well as the importance of considering heterogeneous treatment effects and the local average treatment effect (LATE) in analysis.