This document discusses the use of virtual worlds like Second Life for teaching and learning at the University of Kansas Medical Center. It provides background on how the university integrated virtual worlds into health care courses by purchasing a private virtual island called KUMC Isle. Several projects using the virtual world are described, including having students give speeches in a virtual auditorium, simulate procedures in a virtual operating room, and take part in roleplays as healthcare professionals. Students reported that the virtual world experiences improved their real-world speaking, professionalism, and patient interaction skills. The document concludes with lessons on when virtual worlds are best used versus not used for teaching, and things to consider before beginning a virtual world project like the learning curve and defining learning tasks.