This document discusses the transition between the modernist evidence regime and emerging alternative evidence practices for addressing interconnected health and environmental challenges. It outlines three parts: (1) the assumptions of the modernist evidence regime which values certainty, control and neutrality; (2) the rise of participatory evidence practices that involve communities and value uncertainty, complexity and situated knowledge; (3) questions around whether these alternative practices can thrive and integrate with existing regimes or represent new epistemological approaches needed to tackle wicked problems.