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20BM205 LIFE SCIENCES
TREE OF LIFE
Darwinian evolution & molecular perspective; Introduction to
phylogeny - Classification systems in biology and relationships ;
Cellular assemblies - From single cell to multi-cellular organisms:
Geometry, Structure and Energetics.
MOLECULAR PROCESSES
Gene regulation, protein synthesis, energy metabolism, sensing at the
cell level, rotary motors at the Nano scale, cellular decision
making networks, photosynthesis, embryonic development, cell-cell
communication, physiology, self-organization, self-
repair, evolution, ecosystem dynamics, geochemical ecological cycles,
ecosystem resilience.
20BM205 LIFE SCIENCE
BIOLOGICALLY-INSPIRED INNOVATION IN ENGINEERING
DESIGN10
Introduction to Biomimicry, Design Process- Problem driven BID
process- Solution Driven BID process-Tools; Application of
Biomimetics in artificial intelligence, bioinformatics and computational
biology, robotics, smart materials, medical devices, Biosensors,
architecture and human computer interfaces.
20BM205 LIFE SCIENCE
Course Outcomes:
•Comprehend the key building blocks and processes of life at all levels
of biological organization.
•Recognize engineering problems and find potential biological solutions
by biomimicry approach.
INTRODUCTION TO LIFE SCIENCE (GENERAL CLASSIFICATION INTRO)
The Theory of
Biological
Evolution
INTRODUCTION TO LIFE SCIENCE (GENERAL CLASSIFICATION INTRO)
The Theory of Evolution, defined:
“All living species are descendants of
ancestral species and are different from
present day ones due to the cumulative
change in the genetic composition of a
population”
– Sooo in a nutshell, populations of living
things look and behave differently because
over time, their DNA has changed… but how?
Charles Darwin (1809-1882)
• Father of the theory of Evolution
• Suggested that natural selection is the
mechanism by which species evolve over
geologic time.
• Proposed Descent with Modification:
– All organisms on Earth are related
through some unknown ancestral
type that lived long ago.
HMS BEAGLE
INTRODUCTION TO LIFE SCIENCE (GENERAL CLASSIFICATION INTRO)
INTRODUCTION TO LIFE SCIENCE (GENERAL CLASSIFICATION INTRO)
INTRODUCTION TO LIFE SCIENCE (GENERAL CLASSIFICATION INTRO)
History of the Theory
• Evolutionary theory was developed
through many generations of scientists
interpreting new evidence to refine and
expand our understanding of biological
change across time.
– Darwin and Wallace (Evolution)
– Gregor Mendel (Genetics)
– Franklin, Watson & Crick (Genetics)
Darwin and Wallace (Evolution)
Gregor Mendel (Genetics)
Franklin, Watson & Crick
(Genetics)
The Nuts and Bolts of Evolution
• Evolution: A cumulative change in the
inherited characteristics of population.
• Population!! Is what changes.
• Evolution is like a tree – many branches
emerged from a common beginning, some
branches died off (extinction), others
branched multiple times (present-day
diversity)
INTRODUCTION TO LIFE SCIENCE (GENERAL CLASSIFICATION INTRO)
INTRODUCTION TO LIFE SCIENCE (GENERAL CLASSIFICATION INTRO)
INTRODUCTION TO LIFE SCIENCE (GENERAL CLASSIFICATION INTRO)
INTRODUCTION TO LIFE SCIENCE (GENERAL CLASSIFICATION INTRO)
The Nuts and Bolts of Evolution
• The great diversity of living organisms is the
result of over 3.5 billion years of evolution, filling
every available niche with life forms.
• Niche: The area within a habitat occupied by an
organism OR the ecological role of an organism
within its community.
– “I’ve found my niche in society, I am a social worker”
– “The arctic fish have found their
niche in cold waters due to the
adaptations in their cell membranes”
Niche: The area within a habitat occupied by an organism
OR the function of an organism within its community.
Discuss with your neighbors a possible niche for
– Elephant
– Whale
– Fish
• Why have these life forms filled these niches?
• How have these life forms filled these niches?
The Origin of Species
Darwin developed
two main ideas:
– Evolution
explains life’s
unity and
diversity
– Natural
selection is a
cause of adaptive
evolution
To Darwin, the history of life is like a tree.
multiple branchings from a common trunk to
the tips of the youngest twigs that represent
the diversity of living organisms
Figure 22.7
Hyracoidea
(Hyraxes)
Sirenia
(Manatees
and relatives)
Yea
rs
ago
Millions
of
years
ago
Dein
othe
rium
Mam
mut
Stego
don
Mam
muth
us
Platy
belo
don
Bary
ther
ium
Moe
rithe
rium
Elephas
maximus
(Asia)
Loxodonta
africana
(Africa)
Loxodonta
cyclotis
(Africa)
The Six Main Points of
Darwin’s Theory of Evolution
Observations and Inferences
1. Overproduction*
• Most species produce far more offspring
than are needed to maintain the
population.
• Species populations remain more or less
constant (“stable”) because a small
fraction of offspring live long enough to
reproduce.
INTRODUCTION TO LIFE SCIENCE (GENERAL CLASSIFICATION INTRO)
2. Competition*
• Living space and food are limited, so
offspring from each generation must
compete among themselves in order to
live.
• Only a small fraction can possibly survive
long enough to reproduce.
3. Genetic Variation*
• Characteristics in individuals in any
species are not exactly alike.
– Ex: Differences for Homo sapiens (humans) can be
exact size or shape of body, strength in running, or
resistance to disease.
• These differences are considered to be
the variations within a species. What
causes slight variations between
individuals?
4. Adaptation
An adaptation is an inherited trait that increases
an organisms’ chance of survival and
reproduction in a given environment.
The word “adapt” is a VERBAL
SHORTCUT and I hate it. 
5. Natural Selection*
• Nature/environment selects for living
organisms with better suited inherited
traits to survive and reproduce.
• Variation caused by
within a species (ex: giraffe) may make
them better “equipped” for survival.
• Offspring inherit these better traits, and as
a whole the population improves for that
particular environment.
INTRODUCTION TO LIFE SCIENCE (GENERAL CLASSIFICATION INTRO)
5. Natural Selection, cont.
• Natural Selection does not move in a pre-
determined direction! The changing earth
determines what will and can survive.
INTRODUCTION TO LIFE SCIENCE (GENERAL CLASSIFICATION INTRO)
6. Speciation
• Over many generations, favorable adaptations
(in a particular environment) gradually
accumulate a in species and “bad” ones (in a
particular environment) disappear.
• Eventually, accumulated changes become so
great, the result is a new species.
• Formation of a new species is called
“Speciation” and it takes many, many
generations to do.
6. Speciation
The four factors*
1. Overproduction
2. Competition
3. Genetic Variation
4. Natural Selection
Biological Evolution is a consequence of these
4 factors - they work together to impact any
living population
Which one of Darwin’s Six
Points do the following
pictures show?
Diagram 1
Diagram 2
Diagram 3
Diagram 4
Key
Competition
or
Overpopulation
Variation
Speciation
Adaptation

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INTRODUCTION TO LIFE SCIENCE (GENERAL CLASSIFICATION INTRO)

  • 1. 20BM205 LIFE SCIENCES TREE OF LIFE Darwinian evolution & molecular perspective; Introduction to phylogeny - Classification systems in biology and relationships ; Cellular assemblies - From single cell to multi-cellular organisms: Geometry, Structure and Energetics. MOLECULAR PROCESSES Gene regulation, protein synthesis, energy metabolism, sensing at the cell level, rotary motors at the Nano scale, cellular decision making networks, photosynthesis, embryonic development, cell-cell communication, physiology, self-organization, self- repair, evolution, ecosystem dynamics, geochemical ecological cycles, ecosystem resilience.
  • 2. 20BM205 LIFE SCIENCE BIOLOGICALLY-INSPIRED INNOVATION IN ENGINEERING DESIGN10 Introduction to Biomimicry, Design Process- Problem driven BID process- Solution Driven BID process-Tools; Application of Biomimetics in artificial intelligence, bioinformatics and computational biology, robotics, smart materials, medical devices, Biosensors, architecture and human computer interfaces.
  • 3. 20BM205 LIFE SCIENCE Course Outcomes: •Comprehend the key building blocks and processes of life at all levels of biological organization. •Recognize engineering problems and find potential biological solutions by biomimicry approach.
  • 7. The Theory of Evolution, defined: “All living species are descendants of ancestral species and are different from present day ones due to the cumulative change in the genetic composition of a population” – Sooo in a nutshell, populations of living things look and behave differently because over time, their DNA has changed… but how?
  • 8. Charles Darwin (1809-1882) • Father of the theory of Evolution • Suggested that natural selection is the mechanism by which species evolve over geologic time. • Proposed Descent with Modification: – All organisms on Earth are related through some unknown ancestral type that lived long ago.
  • 13. History of the Theory • Evolutionary theory was developed through many generations of scientists interpreting new evidence to refine and expand our understanding of biological change across time. – Darwin and Wallace (Evolution) – Gregor Mendel (Genetics) – Franklin, Watson & Crick (Genetics)
  • 14. Darwin and Wallace (Evolution)
  • 16. Franklin, Watson & Crick (Genetics)
  • 17. The Nuts and Bolts of Evolution • Evolution: A cumulative change in the inherited characteristics of population. • Population!! Is what changes. • Evolution is like a tree – many branches emerged from a common beginning, some branches died off (extinction), others branched multiple times (present-day diversity)
  • 22. The Nuts and Bolts of Evolution • The great diversity of living organisms is the result of over 3.5 billion years of evolution, filling every available niche with life forms. • Niche: The area within a habitat occupied by an organism OR the ecological role of an organism within its community. – “I’ve found my niche in society, I am a social worker” – “The arctic fish have found their niche in cold waters due to the adaptations in their cell membranes”
  • 23. Niche: The area within a habitat occupied by an organism OR the function of an organism within its community. Discuss with your neighbors a possible niche for – Elephant – Whale – Fish • Why have these life forms filled these niches? • How have these life forms filled these niches?
  • 24. The Origin of Species Darwin developed two main ideas: – Evolution explains life’s unity and diversity – Natural selection is a cause of adaptive evolution
  • 25. To Darwin, the history of life is like a tree. multiple branchings from a common trunk to the tips of the youngest twigs that represent the diversity of living organisms Figure 22.7 Hyracoidea (Hyraxes) Sirenia (Manatees and relatives) Yea rs ago Millions of years ago Dein othe rium Mam mut Stego don Mam muth us Platy belo don Bary ther ium Moe rithe rium Elephas maximus (Asia) Loxodonta africana (Africa) Loxodonta cyclotis (Africa)
  • 26. The Six Main Points of Darwin’s Theory of Evolution Observations and Inferences
  • 27. 1. Overproduction* • Most species produce far more offspring than are needed to maintain the population. • Species populations remain more or less constant (“stable”) because a small fraction of offspring live long enough to reproduce.
  • 29. 2. Competition* • Living space and food are limited, so offspring from each generation must compete among themselves in order to live. • Only a small fraction can possibly survive long enough to reproduce.
  • 30. 3. Genetic Variation* • Characteristics in individuals in any species are not exactly alike. – Ex: Differences for Homo sapiens (humans) can be exact size or shape of body, strength in running, or resistance to disease. • These differences are considered to be the variations within a species. What causes slight variations between individuals?
  • 31. 4. Adaptation An adaptation is an inherited trait that increases an organisms’ chance of survival and reproduction in a given environment. The word “adapt” is a VERBAL SHORTCUT and I hate it. 
  • 32. 5. Natural Selection* • Nature/environment selects for living organisms with better suited inherited traits to survive and reproduce. • Variation caused by within a species (ex: giraffe) may make them better “equipped” for survival. • Offspring inherit these better traits, and as a whole the population improves for that particular environment.
  • 34. 5. Natural Selection, cont. • Natural Selection does not move in a pre- determined direction! The changing earth determines what will and can survive.
  • 36. 6. Speciation • Over many generations, favorable adaptations (in a particular environment) gradually accumulate a in species and “bad” ones (in a particular environment) disappear. • Eventually, accumulated changes become so great, the result is a new species. • Formation of a new species is called “Speciation” and it takes many, many generations to do.
  • 38. The four factors* 1. Overproduction 2. Competition 3. Genetic Variation 4. Natural Selection Biological Evolution is a consequence of these 4 factors - they work together to impact any living population
  • 39. Which one of Darwin’s Six Points do the following pictures show?
  • 44. Key