This document provides guidance on setting comprehension purpose questions (CPQs) for reading. It discusses the importance of having a purpose for reading and exploring different types of purposes. It recommends setting a CPQ before each reading to focus attention and encourage active thinking. The document provides tips for creating effective CPQ's and a process for selecting CPQ's, including brainstorming questions, integrating teacher resources, choosing questions that are answerable from the text but require inference, and selecting different types of questions for initial and subsequent readings. The goal is to help readers set purposeful CPQ's that deepen comprehension.