NASA is exploring various methods of open collaboration and innovation to advance its human health and performance initiatives. It has piloted several programs including challenges on InnoCentive, Yet2.com, and TopCoder to source novel solutions from external experts. NASA has also established the NASA Human Health and Performance Center and the Center of Excellence for Collaborative Innovation to institutionalize these open innovation efforts. The results have included new technologies and algorithms as well as potential partnerships. NASA plans to continue expanding these collaboration methods going forward.