This document discusses an IMD and Cisco initiative called the Global Center for Digital Business Transformation. The Center conducted a survey of over 900 business leaders from 12 industries to assess the state of digital disruption. Key findings include that digital disruption is occurring faster than ever and displacing incumbent companies, but many companies are not adequately addressing this threat. The document advocates that all industries will experience disruption as innovations become exponential, so companies must assess their vulnerability and either disrupt themselves or risk being displaced by new business models.