![Hospitalization, Restricted Activity, and the
Development of Disability Among Older Persons
• Cohort
– March 1998 and October 1999
– potential participants were identified from a computerized list of 3157
age-eligible members from a large health plan in greater New Haven
– screening telephone interview
– in-home assessment.
• Physical frailty
– Timed score of greater than 10 seconds on the rapid gait test (ie, walk
back and forth over a 10-ft [3-m] course as quickly as possible)
– In the absence of a criterion standard, operationalizing physical frailty as
slow gait speed is justified by:
• High face validity
• Clinical feasibility
• Strong epidemiological link to functional decline and disability
JAMA. 2004;292:2115-2124](https://image.slidesharecdn.com/disabilityandfrailty-161121172315/85/Lecture-2-Disability-and-Frailty-13-320.jpg)
Lecture 2: Disability and Frailty
- 1. Lecture 2: Disability and Frailty
- 2. Compression of morbidity and mortality hypotheses
- 3. PNAS 2001 98: 6354-6359
- 4. PNAS 2001 98: 6354-6359
- 5. PNAS 2001 98: 6354-6359
- 9. N. Engl. J. Med. 2006; 355: 695 - 703.
- 10. N. Engl. J. Med. 2006; 355: 695 - 703.
- 12. Frailty: the next stage of chronic disease?
- 13. Hospitalization, Restricted Activity, and the Development of Disability Among Older Persons • Cohort – March 1998 and October 1999 – potential participants were identified from a computerized list of 3157 age-eligible members from a large health plan in greater New Haven – screening telephone interview – in-home assessment. • Physical frailty – Timed score of greater than 10 seconds on the rapid gait test (ie, walk back and forth over a 10-ft [3-m] course as quickly as possible) – In the absence of a criterion standard, operationalizing physical frailty as slow gait speed is justified by: • High face validity • Clinical feasibility • Strong epidemiological link to functional decline and disability JAMA. 2004;292:2115-2124
- 14. Gill, T. M. et al. JAMA 2004;292:2115-2124. Baseline Characteristics of Study Participants*
- 15. Gill, T. M. et al. JAMA 2004;292:2115-2124. Kaplan-Meier Curves for the Development of Disability
- 16. Gill, T. M. et al. JAMA 2004;292:2115-2124. Exposure to Intervening Events per 100 Months According to Disability Status*
- 17. Gill, T. M. et al. JAMA 2004;292:2115-2124. Factors Associated With the Development of Any Disability*
- 18. Gill, T. M. et al. JAMA 2004;292:2115-2124. Association Between New Intervening Events and Disability According to Physical Frailty at Baseline
- 19. Gill, T. M. et al. Arch Intern Med 2006;166:418-423. Numbers and Rates of Transitions From Prefrail State at 18 Months to Subsequent State at 36 Months According to Baseline State*