This lecture discusses metabolism, basal metabolic rate (BMR), and factors that influence total daily energy expenditure (TDEE). It defines key terms like metabolism, catabolism, anabolism, and metabolites. It explains that BMR is the minimum calories needed for basic functions and describes common equations to estimate BMR. TDEE is calculated by adding BMR, thermic effect of feeding, exercise energy expenditure, and non-exercise activity thermogenesis. Indirect calorimetry measures oxygen consumption and is most accurate for measuring resting energy expenditure in intensive care patients.