Lesion complexity
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This document discusses various factors that contribute to lesion complexity in coronary arteries, which can impact outcomes of percutaneous coronary intervention (PCI). It describes several scoring systems that classify lesions based on characteristics like vessel patency, morphology, length, location, calcification, and thrombus presence. Specific lesion features discussed in detail include ostial and angulated lesions, bifurcations, degenerated saphenous vein grafts, calcification, thrombus, total occlusions, and the coronary collateral circulation. Assessing these complexity factors can help identify risks for procedural complications and recurrent events.
Lesion complexity
- 2. • Heterogeneity of the composition, distribution, and location of atherosclerotic plaque within the native coronary artery results in unique patterns of stenosis morphology in patients with CAD • These patterns have been used to identify risk factors for procedural outcome and complications after PCI and to assess the risk for recurrent events in patients who present with an acute coronary syndrome
- 4. Data obtained from 846 lesions undergoing qualitative angiographic analysis at the Washington Hospital Center Angiographic Core Laboratory
- 5. • The Society for Cardiovascular Angiography and Interventions (SCAI) risk score used an ordinal ranking of two composite criteria (vessel patency and complex morphology) to classify lesions into four groups: – Non type C patent – Type C patent – Non type C occluded – Type C occluded
- 6. • The Mayo Clinic Risk Score added the integer scores for the presence of eight morphologic variables and provided a better risk stratification than the ACC/AHA lesion classification for the prediction of cardiovascular complications • whereas the ACC/AHA lesion classification was a better system for identification of angiographic success
- 7. 1. Lesion length 2. Osteal location 3. Angulated lesion 4. Bifurcation lesion 5. Degenerated sephanous venous graft 6. Lesion calcification 7. Thrombus
- 8. Lesion Length • Lesion length may be measured by a number of methods – measurement of the “shoulder-to-shoulder” extent of atherosclerosis narrowed by more than 20% – quantification of the lesion length more than 50% narrowed – estimation of the distance between the proximal and distal angiographically “normal” segment • last method is used most commonly in clinical practice and provides a longer length than more quantitative methods • Diffuse (>20 mm) lesions are associated with reduced procedural success with drug-eluting stents, primarily related to large degrees of late lumen loss and more extensive underlying atherosclerosis
- 9. Ostial Location • Ostial lesions are defined as those arising within 3 mm of origin of the vessel or branch • can be further characterized into aorto-ostial and non–aorto-ostial • Aorto-ostial lesions are often fibrocalcific and rigid, requiring additional ablative devices, such as rotational atherectomy in the presence of extensive calcification, to obtain adequate stent expansion • Positioning of the proximal portion of the stent in the aorto-ostial location so that no more than 1 mm of stent extends into the aorta requires meticulous care • Ostial stenoses that do not involve the aorta may also be more elastic than nonostial lesions and require the same principles for treatment as bifurcation lesions
- 10. Angulated Lesions • Vessel angulation should be measured in the most unforeshortened projection at the site of maximum stenosis using a length of curvature that approximates the balloon length • Angioplasty of angulated lesions increased the risk for: – Dissections – Inability to deliver the stent – Subsequent straightening of the vessel that may predispose to late stent fracture
- 11. Bifurcation Lesions. • The optimal strategic approach for bifurcation lesions remains controversial, and the risk for side branch occlusion during PCI relates to the relative size of the parent and branch vessel, the location of the disease in the parent vessel, and the stenosis severity in the origin of the side branch. In general, placement of one stent is preferable to stent placement in both the parent vessel and side branch
- 12. Degenerated Saphenous Vein Grafts • A serial angiographic study in patients undergoing coronary bypass surgery showed that 25% of SVGs occlude within the first year after coronary bypass surgery • Although a drug-eluting stent may reduce the recurrence rate due to restenosis, only embolic protection devices have reduced procedural complications • The extent of graft degeneration and estimated volume of plaque in the target lesion are independent correlates of increased 30-day major adverse cardiac event rates
- 13. Lesion Calcification • Coronary artery calcium is an important marker for coronary atherosclerosis. • Conventional angiography is moderately sensitive for the detection of extensive lesion calcification but is less sensitive for detection of milder degrees of lesion calcification • Severely calcified lesions tend to be more rigid and undilatable than noncalcified lesions, and rotational atherectomy may be useful before stenting to ensure stent delivery and complete stent expansion
- 14. Thrombus • Although conventional angiography is a relatively insensitive method for detection of coronary thrombus • Presence is associated with a higher risk of procedural complications, primarily relating to embolization of thrombotic debris into the distal circulation • Large, intracoronary thrombi may be treated with a combination of pharmacologic agents (e.g., glycoprotein IIb/IIIa inhibitors) and mechanical devices (e.g., passive aspiration and rheolytic thrombectomy
- 15. TOTAL OCCLUSION • Total coronary occlusion is identified as an abrupt termination of the epicardial vessel • anterograde and retrograde collaterals may be present and are helpful in quantifying the length of the totally occluded segment • Success in passage of a coronary guidewire across the occlusion depends on the occlusion duration and on certain lesion morphologic features, such as bridging collaterals, occlusion length of more than 15 mm, and absence of a “nipple” to guide advancement of the guidewire • presence of a total occlusion remains one of the major reasons for referral of patients for coronary bypass surgery
- 16. CORONARY PERFUSION • Perfusion distal to a coronary stenosis can occur anterograde by means of the native vessel, retrograde through collaterals, or through a coronary bypass graft • The rate of anterograde coronary flow is influenced by both the severity and complexity of the stenosis and the status of the microvasculature
- 17. assess the degree of anterograde coronary reperfusion
- 18. Coronary Collateral Circulation • Networks of small anastomotic branches interconnect the major coronary arteries and serve as precursors for the collateral circulation that maintains myocardial perfusion despite the development of severe proximal atherosclerotic narrowings • Collateral channels may not be seen in patients with normal or mildly diseased coronary arteries because of their small (<200 μm) caliber, but as CAD progresses and becomes more severe (>90% stenosis), a pressure gradient is generated between the anastomotic channels and the distal vessel that is hypoperfused • The trans-stenosis pressure gradient facilitates blood flow through the anastomotic channels, which progressively dilate and eventually become visible as collateral vessels
- 19. A Kugel branch arises from the proximal right coronary artery and extends to the distal posterior descending branch of the right coronary artery
- 20. Bridging collaterals (arrow) connecting the proximal and distal right coronary artery
- 21. A microchannel in the mid–left anterior descending artery (arrow).
- 22. A Vieussens collateral extends from the proximal right coronary artery to the left anterior descending artery (arrow
- 23. • The visible collateral channels arise from – contralateral coronary artery – ipsilateral coronary artery through intracoronary collateral channels – through “bridging” channels that have a serpiginous course from the proximal coronary artery to the coronary artery distal to the occlusion
- 24. • These collaterals may provide up to 50% of anterograde coronary flow in chronic total occlusions and may allow the development of a “protected” region of myocardial perfusion that does not develop ischemia during enhanced myocardial oxygen demands • Recruitment of collateral channels may occur quickly in patients who develop an acute ST- segment elevation myocardial infarction caused by a sudden thrombotic occlusion
- 25. • Other factors that affect collateral development are patency of the arteries supplying the collateral and the size and vascular resistance of the segment distal to the stenosis
- 26. • Grading of flow of collaterals can be classified by the Rentrop criteria – Rentrop grade 0 (no filling) – Rentrop grade 1 (small side branches filled) – Rentrop grade 2 (partial epicardial filling of the occluded artery) – Rentrop grade 3 (complete epicardial filling of the occluded artery)