Liver slides
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The document describes the structure and organization of the liver. The liver contains lobules that are organized in three patterns - classic, portal, and liver acinus. The classic lobule is hexagonal in shape with a central vein in the middle and a portal triad at the boundaries. Portal lobules connect three central veins in a triangle shape. Liver acini are diamond shaped and bordered by two central veins and portal triads. Within the lobules, blood flows through sinusoids while bile flows in bile canaliculi, which is between hepatocytes and bounded by tight junctions, in the opposite direction to blood towards the bile ducts. Lymph flows within the space of disse, located between hepatocytes and sin
Liver slides
- 1. Liver Additional images from: http://www.bu.edu/histology/ and http://w3.ouhsc.edu/histology
- 3. Portal Triad (+ lymph!)
- 4. Portal Triad
- 8. Central Vein
- 9. The Lobules 3 modes of architecture • Classic Lobule – a hexagon with a central vein in the middle and portal triad (hepatic artery, portal vein, bile duct) at boundary points. • Portal Lobule – connects 3 adjacent central veins into a triangle; it follows bile drainage • Liver acinus – diamond shaped and bordered by 2 central veins and portal triads.
- 10. Classic Lobule
- 11. Classic Lobule
- 12. Portal Lobule
- 13. Liver acinus
- 14. Three Lobules 1)CLASSIC 2)PORTAL 3) LIVER ACINUS Shape: Polygon Triangle Ellipse Central Vein: Central 3 tips 2 tips
- 15. Lymph • Endothelium of Sinusoids is fenestrated • Space of Disse = place of exchange of materials between blood and hepatocyte
- 16. Space of Disse
- 17. Space of Disse
- 18. Bile -Made by hepatocytes -Drained into Bile ducts -Moves in opposite direction from blood to portal triad -Nasty stuff – Caniculi are bounded by tight junctions
- 19. Bile Canaliculus
- 20. Bile Canaliculus
- 21. Bile Canaliculus
- 22. Bile Canaliculus: • holds bile • btwn hepatocytes • tight junctions • communicates with bile duct • flows in opposite direction of blood Space of Disse: • holds lymph • communicates with sinusoids via fenstrations and with Space of Moll and lymphatics
- 23. Bile Canaliculus: • holds bile • btwn hepatocytes • bounded by tight junctions • communicates with bile duct • flows in the opposite direction to blood Space of Disse: • holds lymph • communicates with sinusoids via fenstrations and with Space of Moll and lymphatics • flows in the direction of blood
- 24. What is at the pointer? Is it carrying blood/bile to/from hepatocytes?
- 25. Portal Vein
- 26. What is at the pointer? Is it carrying blood/bile to/from hepatocytes?
- 27. Bile duct It is carrying bile from the hepatocytes?
- 28. Other elements
- 29. Kupffer Cell
- 30. Kupffer Cell
- 31. Practice
- 32. Practice your Liver - Silver
- 33. Practice your Liver - Silver
- 34. Liver EM
- 35. Liver EM