NHibernate is an object-relational mapper (ORM) that allows developers to work with objects in code while NHibernate handles the conversion between objects and relational data. The presentation covers what NHibernate is, why it is useful, and how to use it. Key concepts discussed include the unit of work pattern implemented through ISession, mapping objects to tables, querying with HQL and criteria, and lazy loading of related data. The presenter demonstrates NHibernate through code examples and encourages attendees to follow his blog for more information.