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MACROMOLECULES 
Notes Booklet
VOCABULARY 
•Record the following 
terms on back of your 
notes flip booklet
MONOMER 
• A small molecule that can combine 
with other molecules to form polymers 
• A single subunit 
• A building block of polymers
POLYMER 
• A large molecule that consists of repeating, 
linked subunits called monomers 
• Macromolecules
FUNCTIONAL GROUP 
• Clusters or groups of atoms that occur 
together within larger molecules 
• Influence the properties of the larger 
molecules of which they are a part 
• Active in chemical reactions 
• Table of functional groups (4 examples)
KEY CHEMICAL REACTIONS OF BIOMOLECULES 
1.Dehydration Synthesis 
• Monomers are connected by this 
reaction in which two molecules are 
covalently bonded to each other through 
the loss of a water molecule. 
• Each monomer contributes part of the 
water: 
-OH + -H 
aka. Condensation
KEY CHEMICAL REACTIONS OF BIOMOLECULES 
2.Hydrolysis 
• Molecules made of 2 or more 
monomers are broken apart by the 
addition of water. 
• “hydro” = water 
• “lysis” = to split 
• “hydrolysis” = to split with water
MACROMOLECULES BASICS 
•Record the following 
information on the 
FRONT panels of your 
notes booklet.
• Subunits: monosaccharides 
• Elements present: C, H, O with 
the ratio of H:O ≈ 2:1 (H2O) 
• Examples: 
• simple sugars (glucose, 
fructose, sucrose) 
• Starch 
• Cellulose 
• Disaccharides, 
polysaccharides 
• Functions in the body: 
• Energy source (fuel) 
• Structure (building 
material) 
• Cell membrane 
receptors 
(glycoproteins) 
GROUP I: CARBOHYDRATES
• Subunits: glycerol, fatty acids, 
sterols 
• Elements present: C, H, O with the 
ratio of H : O > 2:1 (much, much 
more H than O!); sometimes P 
• Examples: 
• phospholipids, fats (saturated, 
unsaturated), waxes, oils, 
steroids, some pigments 
• Monoglycerides, diglycerides, 
triglycerides 
• Functions in the body: 
• Energy source (fuel) 
• Store energy 
• Structural 
• Protection 
• Cell signaling 
GROUP II: LIPIDS
• Subunits: amino acids 
• Elements present: C, H, O, N 
(sometimes S) 
• Examples: 
• Peptides, dipeptides, 
polypeptides 
• Enzymes 
• Hemoglobin 
• 21 amino acids in the body 
• Functions in the body: 
• Speed up chemical 
reactions, 
• Support 
• Transport 
• Communication 
• Movement 
• Protection 
GROUP III: PROTEINS
• Subunits: nucleotides 
• Elements present: C, H, O, N, P 
• Examples: 
• DNA 
• RNA: mRNA, rRNA, tRNA 
• Functions in the body: 
• Store and transmit 
information 
• Genetic information 
• Genetic code 
GROUP IV: NUCLEIC ACIDS
MACROMOLECULES DETAILS 
•Record the following 
notes INSIDE your notes 
booklet under the 
appropriate flap.
CARBOHYDRATES 
1.Biological Importance 
• Very abundant in nature 
• Photosynthesis directly produces glucose 
• Chemosynthesis produces carbohydrates 
• Cellulose = structural component of plant 
cell walls; is the most abundant biomolecule 
on Earth
CARBOHYDRATES, CON’T 
• Carbohydrates make up the cell walls of many 
diverse organisms 
• Ex: bacteria, fungi, algae 
• Arthropod exoskeletons = chitin 
• Chemical receptors = cell communication 
2. Primary Dietary Sources 
• Plant-based
LIPIDS 
1. Biological Importance 
• Most important trait = lipids do not mix well 
with water 
• Cells would not exist without lipids 
• Phosophlipid bilayer = cell membranes 
• Energy storage 
• Like gasoline molecules 
• Twice as energy-rich as carbohydrates 
• Long-term energy reserves
LIPIDS, CON’T 
• Steroids 
• Chemical communication and regulation 
• Cholesterol helps maintain the structure & 
function of animal cell membranes 
2. Dietary Sources 
• Plant-based: unsaturated fats 
• Animal-based: saturated fats
PROTEINS 
1. Biological Importance 
• Nearly every dynamic function of a living thing 
depends on proteins 
• From the Greek word proteios, meaning “first 
place” 
• Make up more than 50% of the dry mass of 
most cells 
• Instrumental in almost everything organisms 
do
PROTEINS, CON’T 
• Chemical reactions, structural support, storage, 
transport, communication, movement, defense 
mechanisms 
• Life would not be possible without enzymes 
• Proteins are the most structurally sophisticated 
molecules known. 
2. Dietary sources 
• Plant-based 
• Animal-based
NUCLEIC ACIDS 
1. Biological Importance 
• Enable living organisms to reproduce their 
complex components from one generation to the 
next. 
• Store and transmit hereditary information 
• Encoded in DNA is the information that 
programs all of a cell’s activities 
• Determines the amino acid sequence of 
proteins
NUCLEIC ACIDS, CON’T 
• Interestingly, DNA is not directly involved in running the 
operations of a cell 
• Analogy = computer software vs. hardware 
• Tape Measures of Evolution 
• Linear sequences of nucleotides in DNA are passed 
from parent to offspring. 
• Compare sequences among living things to determine 
relatedness and change over time 
2. Dietary sources 
• From any living thing!
HIGH-ENERGY MOLECULES: ATP 
• (These go on the flap page that was added to the nucleic acids flap of the notes booklet.) 
• ATP = adenosine triphosphate 
• Subunits = nucleotides 
• An important source of energy for cellular 
processes. 
• When ATP reacts with water, energy is 
released. 
• Hydrolysis of ATP (phosphate group 
removed) 
• Cells use THAT energy to do work!
ADDITIONAL NOTES 
•Record the following 
notes on lined paper in 
notes section of binder. 
Can be added to the notes 
pages with the cut-out or 
foldable macromolecule 
models.
EMERGENT PROPERTIES IN THE CHEMISTRY OF LIFE 
• Life is organized along a 
hierarchy of structural and 
functional levels. 
•With each new level, new 
properties emerge.
EMERGENT PROPERTIES IN THE CHEMISTRY OF LIFE 
Atoms have 
unique 
properties 
When atoms 
combine to form 
compounds, the 
compounds 
have new and 
unique 
properties 
different from 
their parts. 
Functional 
groups within 
molecules give 
rise to unique 
properties of 
those larger 
molecules.
EMERGENT PROPERTIES IN THE CHEMISTRY OF LIFE 
Monomers have 
unique 
properties. 
When monomers 
combine to form 
polymers, the 
polymers have 
new and unique 
properties 
different from 
their individual 
monomers. 
Macromolecules 
assemble and 
work together to 
give rise to 
more complex 
structures 
leading to the 
next level of the 
hierarchy of life: 
CELL 
ORGANELLES 
AND CELLS.

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Macromolecules notes basic with vocab

  • 2. VOCABULARY •Record the following terms on back of your notes flip booklet
  • 3. MONOMER • A small molecule that can combine with other molecules to form polymers • A single subunit • A building block of polymers
  • 4. POLYMER • A large molecule that consists of repeating, linked subunits called monomers • Macromolecules
  • 5. FUNCTIONAL GROUP • Clusters or groups of atoms that occur together within larger molecules • Influence the properties of the larger molecules of which they are a part • Active in chemical reactions • Table of functional groups (4 examples)
  • 6. KEY CHEMICAL REACTIONS OF BIOMOLECULES 1.Dehydration Synthesis • Monomers are connected by this reaction in which two molecules are covalently bonded to each other through the loss of a water molecule. • Each monomer contributes part of the water: -OH + -H aka. Condensation
  • 7. KEY CHEMICAL REACTIONS OF BIOMOLECULES 2.Hydrolysis • Molecules made of 2 or more monomers are broken apart by the addition of water. • “hydro” = water • “lysis” = to split • “hydrolysis” = to split with water
  • 8. MACROMOLECULES BASICS •Record the following information on the FRONT panels of your notes booklet.
  • 9. • Subunits: monosaccharides • Elements present: C, H, O with the ratio of H:O ≈ 2:1 (H2O) • Examples: • simple sugars (glucose, fructose, sucrose) • Starch • Cellulose • Disaccharides, polysaccharides • Functions in the body: • Energy source (fuel) • Structure (building material) • Cell membrane receptors (glycoproteins) GROUP I: CARBOHYDRATES
  • 10. • Subunits: glycerol, fatty acids, sterols • Elements present: C, H, O with the ratio of H : O > 2:1 (much, much more H than O!); sometimes P • Examples: • phospholipids, fats (saturated, unsaturated), waxes, oils, steroids, some pigments • Monoglycerides, diglycerides, triglycerides • Functions in the body: • Energy source (fuel) • Store energy • Structural • Protection • Cell signaling GROUP II: LIPIDS
  • 11. • Subunits: amino acids • Elements present: C, H, O, N (sometimes S) • Examples: • Peptides, dipeptides, polypeptides • Enzymes • Hemoglobin • 21 amino acids in the body • Functions in the body: • Speed up chemical reactions, • Support • Transport • Communication • Movement • Protection GROUP III: PROTEINS
  • 12. • Subunits: nucleotides • Elements present: C, H, O, N, P • Examples: • DNA • RNA: mRNA, rRNA, tRNA • Functions in the body: • Store and transmit information • Genetic information • Genetic code GROUP IV: NUCLEIC ACIDS
  • 13. MACROMOLECULES DETAILS •Record the following notes INSIDE your notes booklet under the appropriate flap.
  • 14. CARBOHYDRATES 1.Biological Importance • Very abundant in nature • Photosynthesis directly produces glucose • Chemosynthesis produces carbohydrates • Cellulose = structural component of plant cell walls; is the most abundant biomolecule on Earth
  • 15. CARBOHYDRATES, CON’T • Carbohydrates make up the cell walls of many diverse organisms • Ex: bacteria, fungi, algae • Arthropod exoskeletons = chitin • Chemical receptors = cell communication 2. Primary Dietary Sources • Plant-based
  • 16. LIPIDS 1. Biological Importance • Most important trait = lipids do not mix well with water • Cells would not exist without lipids • Phosophlipid bilayer = cell membranes • Energy storage • Like gasoline molecules • Twice as energy-rich as carbohydrates • Long-term energy reserves
  • 17. LIPIDS, CON’T • Steroids • Chemical communication and regulation • Cholesterol helps maintain the structure & function of animal cell membranes 2. Dietary Sources • Plant-based: unsaturated fats • Animal-based: saturated fats
  • 18. PROTEINS 1. Biological Importance • Nearly every dynamic function of a living thing depends on proteins • From the Greek word proteios, meaning “first place” • Make up more than 50% of the dry mass of most cells • Instrumental in almost everything organisms do
  • 19. PROTEINS, CON’T • Chemical reactions, structural support, storage, transport, communication, movement, defense mechanisms • Life would not be possible without enzymes • Proteins are the most structurally sophisticated molecules known. 2. Dietary sources • Plant-based • Animal-based
  • 20. NUCLEIC ACIDS 1. Biological Importance • Enable living organisms to reproduce their complex components from one generation to the next. • Store and transmit hereditary information • Encoded in DNA is the information that programs all of a cell’s activities • Determines the amino acid sequence of proteins
  • 21. NUCLEIC ACIDS, CON’T • Interestingly, DNA is not directly involved in running the operations of a cell • Analogy = computer software vs. hardware • Tape Measures of Evolution • Linear sequences of nucleotides in DNA are passed from parent to offspring. • Compare sequences among living things to determine relatedness and change over time 2. Dietary sources • From any living thing!
  • 22. HIGH-ENERGY MOLECULES: ATP • (These go on the flap page that was added to the nucleic acids flap of the notes booklet.) • ATP = adenosine triphosphate • Subunits = nucleotides • An important source of energy for cellular processes. • When ATP reacts with water, energy is released. • Hydrolysis of ATP (phosphate group removed) • Cells use THAT energy to do work!
  • 23. ADDITIONAL NOTES •Record the following notes on lined paper in notes section of binder. Can be added to the notes pages with the cut-out or foldable macromolecule models.
  • 24. EMERGENT PROPERTIES IN THE CHEMISTRY OF LIFE • Life is organized along a hierarchy of structural and functional levels. •With each new level, new properties emerge.
  • 25. EMERGENT PROPERTIES IN THE CHEMISTRY OF LIFE Atoms have unique properties When atoms combine to form compounds, the compounds have new and unique properties different from their parts. Functional groups within molecules give rise to unique properties of those larger molecules.
  • 26. EMERGENT PROPERTIES IN THE CHEMISTRY OF LIFE Monomers have unique properties. When monomers combine to form polymers, the polymers have new and unique properties different from their individual monomers. Macromolecules assemble and work together to give rise to more complex structures leading to the next level of the hierarchy of life: CELL ORGANELLES AND CELLS.