MapReduce frameworks can provide scalability and fault tolerance for scientific computing in cloud environments. This document analyzes using MapReduce for bioinformatics tasks in clouds and presents AzureMapReduce, a decentralized MapReduce framework for Microsoft Azure. It compares the performance of sequence alignment and assembly using Hadoop, Amazon EMR, and AzureMapReduce on different cloud platforms and instance types. For non I/O intensive workloads, AzureMapReduce and clouds can provide acceptable performance and consistency while leveraging cloud infrastructure services.