The median nerve is formed from two roots in the axilla and supplies muscles in the forearm, hand, and fingers. It is susceptible to compression injuries at the carpal tunnel, between the pronator teres muscles, and at the level of the anterior interosseous nerve branch. Carpal tunnel syndrome causes pain, numbness and weakness in the thumb, index, and middle fingers from compression in the wrist. Treatment involves splinting, injections, or surgical decompression of the carpal tunnel.