Meiosis.ppt..
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The document outlines the process of meiosis, a type of cell division that produces haploid gametes from diploid germ cells through two nuclear divisions, Meiosis I and Meiosis II. It details the stages of meiosis, including prophase, metaphase, anaphase, and telophase, as well as the importance of genetic variation through crossing over. Additionally, it distinguishes meiosis from mitosis and describes gametogenesis, which includes spermatogenesis and oogenesis in male and female reproductive systems, respectively.
Meiosis.ppt..
- 1. DR. ASHISH PATEL Assistant professor Dept. AGB, Veterinary College, AAU, Anand
- 2. The meiotic cell division first time described by Van Beneden in 1883 Meiotic cell division occurs in germ cells of all living organism. During meiosis, the genetic material of a diploid germ cell undergoes two nuclear divisions and resulting in to four haploid daughter cells. Each daughter cells has one half of the number of chromosomes as the parent cell. There are two successive nuclear divisions in meiosis as compared to the one division found in mitosis.
- 3. The two stages of meiosis are 1. Meiosis I 2.Meiosis II Meiosis I also called as Reductional Division Meiosis II also called as Equational Division Before a dividing cell enters meiosis, it undergoes a period of growth called Interphase.
- 7. INTERPHASE The interphase just prior to the entry of cell in to meiosis is known as pre meiotic interphase. During the S phase of pre meiotic interphase, chromosome replication takes place.
- 8. MEIOSIS I Meiosis I separate homologous chromosomes and produce two cells with haploid chromosome number (N) for that reason it is known as Reductional Division. Meiosis I consist of four stages, Prophase I Metaphase I Anaphase I and Telophase I.
- 9. PROPHASE I Prophase I is the longest in duration compared to Prophase in mitosis. It takes about 85 - 95 percent of the total time for meiosis and also much more complex. The Prophase I divided into 5 stages (Le Za Pa Di Dia). Leptotene Zygotene Pachytene Diplotene and Diakinesis
- 10. LEPTOTENE The first stage of Prophase I is called Leptotene or leptonema. All the chromosomes begin to condense, so, they become visible as fine thread. There is marked increase in the nuclear volume. A process of 'homology search' which is essential to the initial pairing of homologs, begins during
- 11. ZYGOTENE The zygotene stage also known as zygonema. This stage begins with the initiation of pairing between homologus chromosomes and it ends with complete pairing. The process of pairing (at end to end) between homologus chromosomes is known as Synapsis (Homologous dyads).
- 12. The syneptonemal complex is form during these zygotene stage. At the completion of zygotene, the paired homologs take the form of bivalents. The number of bivalents in each species is equal to the haploid number.
- 13. PACHYTENE The pachytene stage also known as pachynema. The process of synapsis is complete. The two homologus of each bivalent appears to be attached with each other at one or more points, these attachments are known as chiasmata.
- 14. Crossing over is a precise breakage, swapping and reunion between two non- sister chromatids. Crossovers make new gene combinations and which are an important source of genetic variations in populations.
- 15. DIPLOTENE The diplotene stage also known as diplonema. DNA recombination is complete. The chromatids continue to shorten and thicken and the four sister chromatids in a group is called a tetrad. The synaptonemal complex begins to break down.
- 16. The paired chromatids begin to pull apart, causing the strands to separate longitudinally. The chiasmata tend to become terminalised as the meiotic prophase continues.
- 17. DIAKINESISThe chromomes become shorter and thicker due to condensation. Nucleolus and nuclear envelope disappear towards the end of diakinesis. The spindle apparatus becomes organized. The centrioles migrate away from one another.
- 18. METAPHASE I All the bivalents migrate within a cell migrate to metaphase plate. One homologue is pulled above the metaphase plate, the other below. The centromeres of homologous chromosomes of each bivalent stretch out on either side.
- 19. The centrioles are at opposite poles of the cell. Spindle fibers from one pole of the cell attach to one chromosome and spindle fibers from the opposite pole attach to the homologous chromosome.
- 20. ANAPHASE I Chromosomes move to the opposite poles. The microtubules and the kinetochore fibers interact, which cause the movement. A difference between mitosis and meiosis is that sister chromatids remain joined after metaphase in meiosis I, whereas in mitosis they separate.
- 21. During Anaphase I original chromosomes separate, so reduction in the number of chromosomes from 2N to N number, yet the sister chromatids remain together.
- 22. TELOPHASE I The homologous chromosome complete their migration to the two poles b/c shortning of spindles. The nuclear envelope organized around two groups of chromosomes. The nucleolus also reappears.
- 23. Cytokinesis Cytokinesis involves the formation of a cleavage furrow, resulting in the pocketing of the cell into two cells. At the end of Telophase I and Cytokinesis, two daughter cells are produced, each with one half of the number of chromosomes (haploid set of replicated chromosomes) of the original parent cell.
- 24. INTERKINESIS Interkinesis ( Interphase II ) is similar to interphase
- 25. MEIOSIS IIMeiosis II is the second part of the meiotic process. The Meiosis II consists Prophase II Each dyad is composed of a pair of sister chromatids attached by a common centromere. Metaphase II Centromeres are positioned at the equatorial plane. Anaphase II Centromeres divide and the sister chromatids of each dyad are pulled to opposite poles
- 26. Telophase II One member of each pair of homologous chromosome present in each pole. Each chromosome is referred as monad (a combination of maternal and paternal genetic information). Nuclei reform around chromosomes at the poles. Following cytokinesis and finally four haploid gametes result from a single meiotic event.
- 27. Functions of Meiosis 1. Production of haploid (n) gametes: so, that fertilization restores the normal somatic (2n) chromosome number. 2. Production of tremendous amounts of genetic variation. 3. Segregation of the two alleles of each gene. This take place due to pairing between the two homologues of each chromosome and their separation at the first anaphase.
- 28. 4. Recombination between linked genes due to crossing over during pachytene stage. 5. Meiosis facilitates segregation and independent assortment of chromosomes and genes. 6. In sexually reproducing species, meiosis is essential for the continuity of generation. Because meiosis results in the formation of male and female gametes and union of such gametes leads to the development of zygotes and thereby new individual.
- 29. Mitosis Meiosis 1. Occurs in somatic cells Occurs in reproductive cells 2. One cell produces two daughter cells One cell produces four daughter cells 3. It is an equational division separating sister chromatids. It is a reduction division. The first stage is a reduction division which separates homologous chromosomes at first anaphase. Sister chromatids separate in an equational division at II anaphase. 4. Only one division per cycle i.e. one cytoplasmic division (cytokinesis) per equational division. Two divisions per cycle i.e. two cytoplasmic divisions, one reduction division and equation division. 5. Chromosomes fail to synapse. No chiasmata formation. Chromosomes synapse and form chiasmata. 6. Genetic exchange between homologous chromosomes does not occur. Genetic exchange through chiasmata occurs between homologous chromosomes.
- 30. Mitosis Meiosis 7 Genetic contents of daughter cells are identical. Genetic contents of daughter cells are different. 8 Chromosome number of daughter cells is the same as that of mother cell. Chromosome number of daughter cells is half of that of mother cells. 9 Daughter cells are capable of undergoing additional mitotic divisions. Daughter cells are not capable of undergoing another meiotic division although they may undergo mitotic division. 10 Start at the zygote stage and continues through the life of the organism. Occurs only after puberty, in higher organisms, but occurs in the zygote of algae and fungi.
- 31. GAMETOGENESIS Gametogenesis is the process of production of haploid sex cells. Gametes have one-half the genetic material (haploid chromosome numbers) from the germ cell of each parent. Fusion of spermatozoa and ova at time of fertilization results in a zygote with diploid genome (chromosome numbers). The process of production of spermatozoa is called Spermatogenesis and the process of production of ovum is termed Oogenesis.
- 33. Chrom osomes Process Male Female Male Female Spermatogonium Oogonium Diploid Spermatocytogenesis Oocytogenesis Primary Spermatocyte Primary Oocyte Diploid Spermatidogenesis Ootidogenesis (Folliculogenesis) Secondary Spermatocytes Secondary Oocyte Haploid Spermatidogenesis Ootidogenesis Spermatazoa Ovum Haploid Spermiogenesis
- 34. SPERMATOGENESIS Spermatogenesis is the process of producing sperm cell in the male reproductive organs (testes) through a sequence of cell divisions (spermatocytogenesis) and a metamorphic change (spermiogenesis) to produce spermatozoa. SPERMIOGENESIS The differentiation of the spermatids into sperm cells is called spermiogenesis. Large, spherical, non-motile spermatid is metamorphosed (converted) in to a small, elongated, motile sperm (which possess three parts- head, middle piece and tail).
- 35. Nuclear condensation The nucleus moves to one edge of the cell; Thickening and reduction of the nuclear size; Condensation of the nuclear contents into the smallest space Cytoplasma reduction Elimination of all unnecessary cytoplasm Acrosome formation Golgi apparatus produces the acrosome containing enzymes and it takes its place around the anterior end of the sperm head. It plays an important role in the penetration through the pellucid zone of the oocyte. Flagellum formation Form the sperm cell tail
- 36. OOGENESIS Oogenesis is the process of meiosis in female organisms from an oogonium to a primary oocyte and from primary oocyte to a secondary oocyte, and then to an ovum. The gamete formed by oogenesis contains a haploid nucleus and the oogenesis also builds up a store of cytoplasmic enzymes, mRNAs, organelles, and metabolic substrates. During the first division of oogenic meiosis, unequal cytokinesis take place and result in one of the two daughter cells containing hardly any cytoplasm, whereas the other cell has nearly the entire volume of cellular constituents.
- 37. The smaller cell is called the first polar body, and the larger cell is called as the secondary oocyte. During the second division of meiosis, a similar unequal cytokinesis takes place in secondary oocyte and result in one large cell (ovum), and a small cell (second polar body). The polar bodies receive the same chromosome complement as the secondary oocyte and ovum, but are not functional sex cells. Because of accumulation of nutrient materials, an egg is usually much larger than a sperm of the same species.